3D-Printed Drug Delivery Systems: The Effects of Drug Incorporation Methods on Their Release and Antibacterial Efficiency

Bahaa Shaqour , Inés Reigada , Żaneta Górecka , Emilia Choińska , Bart Verleije , Koen Beyers , Wojciech Święszkowski , Adyary Fallarero , Paul Cos

Abstract

Additive manufacturing technologies have been widely used in the medical field. More specifically, fused filament fabrication (FFF) 3D-printing technology has been thoroughly investigated to produce drug delivery systems. Recently, few researchers have explored the possibility of directly 3D printing such systems without the need for producing a filament which is usually the feedstock material for the printer. This was possible via direct feeding of a mixture consisting of the carrier polymer and the required drug. However, as this direct feeding approach shows limited homogenizing abilities, it is vital to investigate the effect of the pre-mixing step on the quality of the 3D printed products. Our study investigates the two commonly used mixing approaches—solvent casting and powder mixing. For this purpose, polycaprolactone (PCL) was used as the main polymer under investigation and gentamicin sulfate (GS) was selected as a reference. The produced systems’ efficacy was investigated for bacterial and biofilm prevention. Our data show that the solvent casting approach offers improved drug distribution within the polymeric matrix, as was observed from micro-computed topography and scanning electron microscopy visualization. Moreover, this approach shows a higher drug release rate and thus improved antibacterial efficacy. However, there were no differences among the tested approaches in terms of thermal and mechanical properties.
Author Bahaa Shaqour
Bahaa Shaqour,,
-
, Inés Reigada
Inés Reigada,,
-
, Żaneta Górecka (FMSE / DMD)
Żaneta Górecka,,
- Division of Materials Design
, Emilia Choińska (FMSE / DMD)
Emilia Choińska,,
- Division of Materials Design
, Bart Verleije
Bart Verleije,,
-
, Koen Beyers
Koen Beyers,,
-
, Wojciech Święszkowski (FMSE / DMD)
Wojciech Święszkowski,,
- Division of Materials Design
, Adyary Fallarero
Adyary Fallarero,,
-
, Paul Cos
Paul Cos,,
-
Journal seriesMaterials, ISSN 1996-1944
Issue year2020
Vol13
No15
Pages1-16
Publication size in sheets0.75
Article number3364
Keywords in Englishfused filament fabrication; 3D printing; drug loading; drug release
ASJC Classification2500 General Materials Science
DOIDOI:10.3390/ma13153364
URL https://www.mdpi.com/1996-1944/13/15/3364
Languageen angielski
LicenseJournal (articles only); author's original; Uznanie Autorstwa (CC-BY); after publication
File
materials-13-03364.pdf 2.51 MB
Score (nominal)140
Score sourcejournalList
ScoreMinisterial score = 140.0, 16-09-2020, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2017 = 1.285; WoS Impact Factor: 2018 = 2.972 (2) - 2018=3.532 (5)
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