Experimental analysis of the deposition of aerosol droplets in the upper airways of human
Authors:
- Tomasz Robert Sosnowski
Abstract
This chapter presents some examples of the application of chemical engineering approach in solving problems of drug delivery using aerosolized liquids. Both aerosol formation and the subsequent transport of micrometer-sized droplets through the upper airways of human: nose, mouth and throat, have been investigated by experiments “in vitro” on anatomical models of these parts of the respiratory system. The results allowed to identify the basic physicochemical and aerodynamic/mass transfer phenomena which are responsible for the local separation of aerosol droplets from the air stream and their deposition and displacement in the studied regions of the human body. The influence of liquid properties (e.g., the surface tension, rheological characteristics) and inhalation dynamics have been shown to be essential factors for predicting the efficiency of drug delivery using aerosols.
- Record ID
- WUT402079e0854c403fa1e7407a45d0436f
- Author
- Pages
- 423-429
- Publication size in sheets
- 0.50
- Article number
- 44
- Book
- Ochowiak Marek, Marek Ochowiak Woziwodzki Szymon, Szymon Woziwodzki Mitkowski Piotr Tomasz Piotr Tomasz Mitkowski [et al.] (eds.): Practical aspects of chemical engineering. Selected contributions from PAIC 2019, 2020, Cham (Switzerland), Springer, 499 p., ISBN 978-3-030-39866-8. DOI:10.1007/978-3-030-39867-5 Opening in a new tab
- DOI
- DOI:10.1007/978-3-030-39867-5_44 Opening in a new tab
- Language
- (en) English
- Score (nominal)
- 20
- Score source
- publisherList
- Score
- = 20.0, 08-05-2022, ChapterFromConference
Share
- Uniform Resource Identifier
- https://repo.pw.edu.pl/info/article/WUT402079e0854c403fa1e7407a45d0436f/
- URN
urn:pw-repo:WUT402079e0854c403fa1e7407a45d0436f
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