TASTE MASKING OF ROXITHROMYCIN BY SPRAY DRYING TECHNIQUE

K. Sollohub , M. Jańczyk , A. Kutyła-Olesiuk , H. Wosicka , Patrycja Ciosek , K. Cal

Abstract

The aim of this study was to obtain microencapsulated roxithromycin with highly efficient tastemasking effect of this bitter drug. As a powerful tool for particle engineering, the spray drying technique was chosen for roxithromycin microencapsulation, and Eudragit L30D-55 (methacrylic acid - ethyl acrylate copolymer (1:1) dispersion 30%) was used to form a taste-masking coat. The taste of formulated microcapsules was evaluated by the electronic tongue. Electronic tongue sensor arrays are state-of-the-art tools, which can be used for instrumental taste evaluation of pharmaceuticals. Up to date the only method approved for taste estimation is human taste panel, which suffers from ethical (especially in children), safety and economical concerns. Studies of electronic tongues development and validation in pharmaceutical sciences are subject of great interest nowadays.
Author K. Sollohub
K. Sollohub,,
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, M. Jańczyk
M. Jańczyk,,
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, A. Kutyła-Olesiuk
A. Kutyła-Olesiuk,,
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, H. Wosicka
H. Wosicka,,
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, Patrycja Ciosek (FC / IBC / DM)
Patrycja Ciosek,,
- Department Of Microbioanalytics
, K. Cal
K. Cal,,
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Journal seriesActa Poloniae Pharmaceutica -Drug Research, ISSN 0001-6837, (A 15 pkt)
Issue year2011
Vol68
Pages601-604
Keywords in Englishroxithromycin, spray drying, taste masking, electronic tongue
ASJC Classification3003 Pharmaceutical Science; 3004 Pharmacology
Internal identifier4190
Languageen angielski
Score (nominal)15
Publication indicators WoS Citations = 7; Scopus SNIP (Source Normalised Impact per Paper): 2011 = 0.472; WoS Impact Factor: 2011 = 0.663 (2) - 2012=0.71 (5)
Citation count*5 (2016-05-09)
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