TASTE MASKING OF ROXITHROMYCIN BY SPRAY DRYING TECHNIQUE
K. Sollohub , M. Jańczyk , A. Kutyła-Olesiuk , H. Wosicka , Patrycja Ciosek , K. Cal
AbstractThe aim of this study was to obtain microencapsulated roxithromycin with highly efficient tastemasking effect of this bitter drug. As a powerful tool for particle engineering, the spray drying technique was chosen for roxithromycin microencapsulation, and Eudragit L30D-55 (methacrylic acid - ethyl acrylate copolymer (1:1) dispersion 30%) was used to form a taste-masking coat. The taste of formulated microcapsules was evaluated by the electronic tongue. Electronic tongue sensor arrays are state-of-the-art tools, which can be used for instrumental taste evaluation of pharmaceuticals. Up to date the only method approved for taste estimation is human taste panel, which suffers from ethical (especially in children), safety and economical concerns. Studies of electronic tongues development and validation in pharmaceutical sciences are subject of great interest nowadays.
|Journal series||Acta Poloniae Pharmaceutica -Drug Research, ISSN 0001-6837, (A 15 pkt)|
|Keywords in English||roxithromycin, spray drying, taste masking, electronic tongue|
|Publication indicators||= 7; : 2011 = 0.472; : 2011 = 0.663 (2) - 2012=0.71 (5)|
|Citation count*||5 (2016-05-09)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.