Hodgkin lymphoma of the elderly patients: a retrospective multicenter analysis from the Polish Lymphoma Research Group
Tomasz Wróbel , Przemysław Biecek , J. Rybka , Anna Szulgo , Natalia Sorbotten , Agnieszka Giza , Agata Tyczyńska , Elżbieta Nowara , Agnieszka Badora-Rybicka , K Adamowicz , Waldemar Kulikowski , Renata Kroll-Balcerzak , Andrzej Balcerzak , S. Wojciech , Ewa Kalinka-Warzocha , Beata Kumiega , Joanna Drozd-Sokołowska , Edyta Subocz , Agata Sałek , Maciej Machaczka , Jadwiga Hołojda , Joanna Pogrzeba , Olga Dobrzyńska , Ewa Chmielowska , Wojciech Jurczak , Wanda Knopińska-Posłuszny , Krzysztof Leśniewski-Kmak , Jan Maciej Zaucha
AbstractWe retrospectively analyzed long-term disease outcome of 350 elderly Hodgkin Lymphoma (eHL) patients treated with ABVD/ABVD-like regimen enrolled in the PLRG-R9 study between 2001 and 2013 in Poland. Complete remission was reported for 73% of early (ES) and 61% advanced stage (AS) patients. Nine (10%) ES and 56 (20%) AS patients have died. With the median follow-up of 36 (1–190) months, 3-year EFS and OS was 0.74 (95%CI: 0.63–0.85) and 0.90 (95%CI: 0.82–0.98) for ES; 0.51 (95%CI: 0.44–0.57), and 0.81 (95%CI: 0.75–0.86) for AS patients, respectively. For ES patients, Cox regression revealed ECOG <2 and age >70 as predictive for inferior OS and EFS. For AS patients, the most predictive for OS was the presence of cardiovascular disorders (CVD) (p = .00044), while for EFS four factors were significantly associated with a poor outcome: ECOG< 2, age >70 years, CVD and extranodal disease. In conclusion, CVD significantly impacts outcomes of ABVD-treated advanced eHL patients.
|Journal series||Leukemia & Lymphoma, ISSN 1042-8194|
|Publication size in sheets||0.5|
|Keywords in English||Hodgkin lymphoma, elderly patients, ABVD treatment|
|ASJC Classification||; ;|
|Score||= 70.0, 16-06-2020, ArticleFromJournal|
|Publication indicators||= 1; = 3; : 2016 = 0.664; : 2018 = 2.674 (2) - 2018=2.418 (5)|
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