Hodgkin lymphoma of the elderly patients: a retrospective multicenter analysis from the Polish Lymphoma Research Group

Tomasz Wróbel , Przemysław Biecek , J. Rybka , Anna Szulgo , Natalia Sorbotten , Agnieszka Giza , Agata Tyczyńska , Elżbieta Nowara , Agnieszka Badora-Rybicka , K Adamowicz , Waldemar Kulikowski , Renata Kroll-Balcerzak , Andrzej Balcerzak , S. Wojciech , Ewa Kalinka-Warzocha , Beata Kumiega , Joanna Drozd-Sokołowska , Edyta Subocz , Agata Sałek , Maciej Machaczka , Jadwiga Hołojda , Joanna Pogrzeba , Olga Dobrzyńska , Ewa Chmielowska , Wojciech Jurczak , Wanda Knopińska-Posłuszny , Krzysztof Leśniewski-Kmak , Jan Maciej Zaucha

Abstract

We retrospectively analyzed long-term disease outcome of 350 elderly Hodgkin Lymphoma (eHL) patients treated with ABVD/ABVD-like regimen enrolled in the PLRG-R9 study between 2001 and 2013 in Poland. Complete remission was reported for 73% of early (ES) and 61% advanced stage (AS) patients. Nine (10%) ES and 56 (20%) AS patients have died. With the median follow-up of 36 (1–190) months, 3-year EFS and OS was 0.74 (95%CI: 0.63–0.85) and 0.90 (95%CI: 0.82–0.98) for ES; 0.51 (95%CI: 0.44–0.57), and 0.81 (95%CI: 0.75–0.86) for AS patients, respectively. For ES patients, Cox regression revealed ECOG <2 and age >70 as predictive for inferior OS and EFS. For AS patients, the most predictive for OS was the presence of cardiovascular disorders (CVD) (p = .00044), while for EFS four factors were significantly associated with a poor outcome: ECOG< 2, age >70 years, CVD and extranodal disease. In conclusion, CVD significantly impacts outcomes of ABVD-treated advanced eHL patients.
Author Tomasz Wróbel
Tomasz Wróbel,,
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, Przemysław Biecek (FMIS / DCSDCAM)
Przemysław Biecek,,
- Department of CAD/CAM Systems Design and Computer-Aided Medicine
, J. Rybka
J. Rybka,,
-
, Anna Szulgo
Anna Szulgo,,
-
, Natalia Sorbotten
Natalia Sorbotten,,
-
, Agnieszka Giza
Agnieszka Giza,,
-
, Agata Tyczyńska
Agata Tyczyńska,,
-
, Elżbieta Nowara
Elżbieta Nowara,,
-
, Agnieszka Badora-Rybicka
Agnieszka Badora-Rybicka,,
-
, K Adamowicz
K Adamowicz,,
-
et al.`
Journal seriesLeukemia & Lymphoma, ISSN 1042-8194, (A 25 pkt)
Issue year2019
Vol60
No2
Pages341-348
Publication size in sheets0.5
Keywords in EnglishHodgkin lymphoma, elderly patients, ABVD treatment
ASJC Classification1306 Cancer Research; 2730 Oncology; 2720 Hematology
DOIDOI:10.1080/10428194.2018.1482539
URL https://www.tandfonline.com/doi/abs/10.1080/10428194.2018.1482539
Languageen angielski
Score (nominal)25
ScoreMinisterial score = 25.0, 13-05-2019, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2016 = 0.664; WoS Impact Factor: 2017 = 2.644 (2) - 2017=2.493 (5)
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