Alteration of biophysical activity of pulmonary surfactant by aluminosilicate nanoparticles

Dorota Kondej , Tomasz Robert Sosnowski


The influence of five different types of aluminosilicate nanoparticles (NPs) on the dynamic surface activity of model pulmonary surfactant (PS) (Survanta) was studied experimentally using oscillating bubble tensiometry. Bentonite, halloysite and montmorillonite (MM) NPs, which are used as fillers of polymer composites, were characterized regarding the size distribution, morphology and surface area. Particle doses applied in the studies were estimated based on the inhalation rate and duration, taking into account the expected aerosol concentration and deposition efficiency after penetration of NPs into the alveolar region. The results indicate that aluminosilicate NPs at concentrations in the pulmonary liquid above 0.1 mg cm−3 are capable of promoting alterations of the original dynamic biophysical activity of the PS. This effect is indicated by deviation of the minimum surface tension, stability index and the size of surface tension hysteresis. Such response is dependent on the type of NPs present in the system and is stronger when particle concentration increases. It is suggested that interactions between NPs and the PS must be related to the surfactant adsorption on the suspended particles, while in the case of surface-modified clay NPs the additional washout of surface-active components may be expected. It is speculated that observed changes in surface properties of the surfactant may be associated with undesired health effects following extensive inhalation of aluminosilicate NPs in the workplace.
Author Dorota Kondej - [Centralny Instytut Ochrony Pracy - Państwowy Instytut Badawczy (CIOP PIB)]
Dorota Kondej,,
- Centralny Instytut Ochrony Pracy - Państwowy Instytut Badawczy
, Tomasz Robert Sosnowski (FCPE / CIPE)
Tomasz Robert Sosnowski,,
- Chair of Integrated Process Engineering
Journal seriesInhalation Toxicology, ISSN 0895-8378
Issue year2013
Publication size in sheets0.5
Keywords in Englishadsorption, clay NPs, dynamic surface tension, lung surfactants, nanofilters
ASJC Classification2307 Health, Toxicology and Mutagenesis; 3005 Toxicology
Languageen angielski
Score (nominal)30
Score sourcejournalList
ScoreMinisterial score = 30.0, 01-04-2020, ArticleFromJournal
Ministerial score (2013-2016) = 30.0, 01-04-2020, ArticleFromJournal
Publication indicators WoS Citations = 27; Scopus Citations = 28; GS Citations = 38.0; Scopus SNIP (Source Normalised Impact per Paper): 2013 = 0.869; WoS Impact Factor: 2013 = 2.344 (2) - 2013=2.612 (5)
Citation count*40 (2020-09-20)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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