Drug-core double emulsions for co-release of active ingredients
Ewa Dłuska , Agnieszka Markowska-Radomska , Agata Metera , Waldemar Tomaszewski
AbstractThe paper presents the results of the release process of two encapsulated drugs from double emulsions. Double emulsions have been proposed and discussed as a promising carriers of a few drugs for effective multidrug therapy. Double emulsions were formed by one step method in a Couette-Taylor flow (CTF) bioreactor. Emulsions of O1/W/O2 type with different structures were obtained. Experimental release study involved the influence of process parameters in the CTF bioreactor (liquid flow rates, rotational frequency of inner cylinder of the bioreactor and its annular gap) on the release rates of two entrapped model active agents from internal droplets to external continuous phase of emulsions. Simultaneous release of active agents entrapped in O1/W/O2 emulsions proceed as two steps process. In the first step the simultaneous release of both substances has been observed, whereas in the second step only remain substance having larger molecule. The results shown the influence of the preparation conditions on the kinetics of the release process.
|Journal series||International Journal of Chemical Engineering and Applications, ISSN 2010-0221|
|Publication size in sheets||0.5|
|Keywords in Polish||emulsje wielokrotne, enkapsulacja, proces uwalniania, bioreaktor|
|Keywords in English||multiple emulsions, encapsulation, release process, bioreactor|
|Score|| = 0.0, 05-09-2019, ArticleFromJournal|
= 5.0, 05-09-2019, ArticleFromJournal
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