Drug-core double emulsions for co-release of active ingredients

Ewa Dłuska , Agnieszka Markowska-Radomska , Agata Metera , Waldemar Tomaszewski

Abstract

The paper presents the results of the release process of two encapsulated drugs from double emulsions. Double emulsions have been proposed and discussed as a promising carriers of a few drugs for effective multidrug therapy. Double emulsions were formed by one step method in a Couette-Taylor flow (CTF) bioreactor. Emulsions of O1/W/O2 type with different structures were obtained. Experimental release study involved the influence of process parameters in the CTF bioreactor (liquid flow rates, rotational frequency of inner cylinder of the bioreactor and its annular gap) on the release rates of two entrapped model active agents from internal droplets to external continuous phase of emulsions. Simultaneous release of active agents entrapped in O1/W/O2 emulsions proceed as two steps process. In the first step the simultaneous release of both substances has been observed, whereas in the second step only remain substance having larger molecule. The results shown the influence of the preparation conditions on the kinetics of the release process.