In vitro study on the aerosol emitted from the DPI inhaler under two unsteady inhalation profiles

Agata Dorosz , Agata Bożena Penconek , Arkadiusz Moskal

Abstract

The aim of the current work was to investigate the assumption that: dynamics of inspiration affects the aerosol characteristics emitted from the passive dry powder inhaler and, subsequently, influences the total quantity of drug penetrating lower respiratory tract. Real-time aerosol behavior of the spray-dried powder was studied experimentally utilizing New Generation Cyclohaler for two breathing curves, at the outlet of the inhaler. Aerosol characterization was done by laser diffraction, reliably capturing the aspects of time dependency. It resulted in time evolution of volumetric particle size distribution and was extended with the analysis of local particle dynamics over the studied cross-section. Results presented in the paper confirm its assumption to be true. Different inhalation curves were associated with substantially different inhaler performances. The quicker and more forceful curve II produced better dispersion. Aerosol dynamics is particularly susceptible to the strong aerodynamic effects of unsteadiness acquired from relatively small values of flow rates. The initial part of inspiration may contribute to achieving higher respirable dose content before the peak inspiratory flow is attained. Deaggregation upon impactions with chamber wall and subsequent collisions with grid are assumed to produce desired fine particle fraction. The paper elucidates the relevance of considering time-varying character of inspiration.
Author Agata Dorosz KIPZ
Agata Dorosz,,
- Chair of Integrated Process Engineering
, Agata Bożena Penconek KIPZ
Agata Bożena Penconek,,
- Chair of Integrated Process Engineering
, Arkadiusz Moskal KIPZ
Arkadiusz Moskal,,
- Chair of Integrated Process Engineering
Journal seriesJournal of Aerosol Science, ISSN 0021-8502
Issue year2016
Vol101
Pages104-117
Publication size in sheets0.6
Keywords in Englishunsteady flow, inhalation profile, DPI, aerosol dynamics, particle size characteristics, laser diffraction
DOIDOI:10.1016/j.jaerosci.2016.07.014
URL http://dx.doi.org/10.1016/j.jaerosci.2016.07.014
Languageen angielski
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Dorosz A. (i in.) - In vitro study....pdf 2.9 MB
Score (nominal)35
ScoreMinisterial score = 35.0, 28-11-2017, ArticleFromJournal
Ministerial score (2013-2016) = 35.0, 28-11-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 2.042 (2) - 2016=2.511 (5)
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