In vitro evaluation of degradable electrospun polylactic acid/bioactive calcium phosphate ormoglass scaffolds

Anna Majchrowicz , Agata Roguska , Agnieszka Krawczyńska , Małgorzata Lewandowska , Joan Marti-Munoz , Elisabeth Engel , Oscar Castano

Abstract

Nowadays, the main limitation for clinical application of scaffolds is considered to be an insufficient vascularization of the implanted platforms and healing tissues. In our studies, we proposed a novel PLA-based hybrid platform with aligned and random fibrous internal structure and incorporated calcium phosphate (CaP) ormoglass nanoparticles (0, 10, 20 and 30 wt%) as an off-the-shelf method for obtaining scaffolds with pro-angiogenic properties. Complex morphological and physicochemical evaluation of PLA–CaP ormoglass composites was performed before and after in vitro degradation test in SBF solution to assess their biological potential. The degradation process of PLA–CaP ormoglass composites was accompanied by numerous CaP-based precipitations with extended topography and cauliflower-like shape which may enhance bonding of the material with the bone tissue and accelerate the regenerative process. Random fiber orientation was preferable for CaP compounds deposition upon in vitro degradation. CaP compounds precipitated firstly for randomly oriented composite nonwovens with 20 and 30 wt% addition of ormoglass. Moreover, the preliminary bioactivity test has shown that BSA adsorbed to PLA–CaP ormoglass composites (both aligned and randomly oriented) with 20 and 30 wt% of ormoglass nanoparticles which was not observed for pure PLA scaffolds.

Author Anna Majchrowicz (FMSE)
Anna Majchrowicz,,
- Faculty of Materials Science and Engineering
, Agata Roguska - Institute of Physical Chemistry Polish Academy of Sciences (IChF PAN) [Polish Academy of Sciences (PAN)]
Agata Roguska,,
-
, Agnieszka Krawczyńska (FMSE / DMD)
Agnieszka Krawczyńska,,
- Division of Materials Design
, Małgorzata Lewandowska (FMSE / DMD)
Małgorzata Lewandowska,,
- Division of Materials Design
, Joan Marti-Munoz - Institute for Bioengineering of Catalonia
Joan Marti-Munoz,,
-
, Elisabeth Engel - Institute for Bioengineering of Catalonia
Elisabeth Engel,,
-
, Oscar Castano - Institute for Bioengineering of Catalonia
Oscar Castano,,
-
Journal seriesArchives of Civil and Mechanical Engineering, ISSN 1644-9665, e-ISSN 2083-3318
Issue year2020
Vol20
Pages1-11
Publication size in sheets0.5
Keywords in EnglishComposites; PLA; Calcium phosphate ormoglass; Electrospinning; Degradation
ASJC Classification2205 Civil and Structural Engineering; 2210 Mechanical Engineering
DOIDOI:10.1007/s43452-020-00052-y
URL https://doi.org/10.1007/s43452-020-00052-y
Languageen angielski
File
2020 Arch Civ Mech Eng Majcrowicz.pdf 2.72 MB
Score (nominal)140
Score sourcejournalList
ScoreMinisterial score = 140.0, 24-06-2020, ArticleFromJournal
Publication indicators Scopus Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 2.064; WoS Impact Factor: 2018 = 2.846 (2) - 2018=2.805 (5)
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