3D tissue modelling of skeletal muscle tissue

Marco Costantini , Stefano Testa , Chiara Rinoldi , Nehar Celikkin , Joanna Idaszek , C. Colosi , Andrea Barbetta , Cesare Gargioli , Wojciech Święszkowski

Abstract

Skeletal muscle tissue exhibits endogenous ability to regenerate. However, the self-repair mechanism is restricted only to small damages. The increasing number of extensive injuries of skeletal muscles due to various accidents, more active life-style or cancer resection, combined with the shortcomings of the conventional treatment procedures, creates demand for new, more advanced solutions. Muscle tissue engineering (TE) appears as a promising strategy for fabrication of tissue substitutes from biomaterials, cells and bioactive factors, alone or combined. In this chapter, we present current state of the art of regeneration and engineering of skeletal muscle tissue. The chapter begins with a brief introduction to structure and functions of skeletal muscle tissue, followed by discussion of cells with potential for repair of muscle injuries and dysfunctions. Next, we provide an overview of natural and synthetic biomaterials used in skeletal muscle TE, as well as description of techniques used to process the biomaterials into scaffolds. We also highlight the importance of mechanical and electrical stimulation during in vitro culture and their effect on cell differentiation and maturation. Last but not least, the latest results of in vivo studies are reported. The chapter is concluded with a short summary and outlook on future developments.
Author Marco Costantini - Università Campus Bio-Medico di Roma, Rome, Italy
Marco Costantini,,
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, Stefano Testa - University of Rome Tor Vergata (UNIROMA2)
Stefano Testa,,
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, Chiara Rinoldi (FMSE / DMD)
Chiara Rinoldi,,
- Division of Materials Design
, Nehar Celikkin (FMSE / DMD)
Nehar Celikkin,,
- Division of Materials Design
, Joanna Idaszek (FMSE / DMD)
Joanna Idaszek,,
- Division of Materials Design
, C. Colosi
C. Colosi,,
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, Andrea Barbetta - Sapienza University of Rome
Andrea Barbetta,,
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, Cesare Gargioli - University of Rome Tor Vergata (UNIROMA2)
Cesare Gargioli,,
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, Wojciech Święszkowski (FMSE / DMD)
Wojciech Święszkowski,,
- Division of Materials Design
Pages184-216
Publication size in sheets1.6
Book Cho Dong-Woo (eds.): Biofabrication and 3D Tissue Modeling, Biomaterials Science Series, 2019, Royal Society of Chemistry, ISBN 978-1-78801-198-3, DOI:10.1039/9781788012683
DOIDOI:10.1039/9781788012683
URL https://pubs.rsc.org/en/content/ebook/978-1-78801-198-3
Languageen angielski
Score (nominal)20
Score sourcepublisherList
ScoreMinisterial score = 20.0, 20-10-2019, MonographChapterAuthor
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