Poly(Lactic Acid) (PLA) for biomedical application – synthesis of biocompatible Mg catalyst and optimalization of its use in polymerization of lactide with aid of DOE
Agnieszka Gadomska-Gajadhur , Ludwik Synoradzki , Paweł Ruśkowski
AbstractEfficient, original synthesis of magnesium 2-ethylohexanoate via reaction of metallic magnesium with 2-etylohexanoic acid was achieved. The activity of MgOct2 as biocompatible catalyst of lactide ring opening polymerization was examined. The process was successfully optimized by using factorial and rotatable designs. PLA of Mw =34 000 g/mol with high lactide conversion (>95%) has been obtained. Due to the use of biocompatible catalyst (lack of tin),it can be used in medical and pharmaceutical application.
|Journal series||Organic Process Research & Development, ISSN 1083-6160, (A 35 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||poly(lactic acid), ROP, magnesium compounds, biomedical applications, DOE|
|Abstract in Polish||xxx|
|Score|| = 35.0, 11-03-2019, ArticleFromJournal|
= 35.0, 11-03-2019, ArticleFromJournal
|Publication indicators||= 1; : 2017 = 0.978; : 2017 = 3.584 (2) - 2017=3.109 (5)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.