Poly(Lactic Acid) (PLA) for biomedical application – synthesis of biocompatible Mg catalyst and optimalization of its use in polymerization of lactide with aid of DOE

Agnieszka Gadomska-Gajadhur , Ludwik Synoradzki , Paweł Ruśkowski

Abstract

Efficient, original synthesis of magnesium 2-ethylohexanoate via reaction of metallic magnesium with 2-etylohexanoic acid was achieved. The activity of MgOct2 as biocompatible catalyst of lactide ring opening polymerization was examined. The process was successfully optimized by using factorial and rotatable designs. PLA of Mw =34 000 g/mol with high lactide conversion (>95%) has been obtained. Due to the use of biocompatible catalyst (lack of tin),it can be used in medical and pharmaceutical application.
Author Agnieszka Gadomska-Gajadhur (FC / LTP)
Agnieszka Gadomska-Gajadhur,,
- Laboratory Of Technological Processes
, Ludwik Synoradzki (FC / LTP)
Ludwik Synoradzki,,
- Laboratory Of Technological Processes
, Paweł Ruśkowski (FC / LTP)
Paweł Ruśkowski,,
- Laboratory Of Technological Processes
Journal seriesOrganic Process Research & Development, ISSN 1083-6160, (A 35 pkt)
Issue year2018
Vol22
No9
Pages1167-1173
Publication size in sheets0.5
Keywords in Englishpoly(lactic acid), ROP, magnesium compounds, biomedical applications, DOE
Abstract in Polishxxx
DOIDOI:10.1021/acs.oprd.8b00165
Languageen angielski
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wdpb_publikacje_pliki_plik_publikacja_3530_org.pdf 770.45 KB
Score (nominal)35
ScoreMinisterial score = 35.0, 24-09-2018, ArticleFromJournal
Ministerial score (2013-2016) = 35.0, 24-09-2018, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 2.857 (2) - 2016=2.801 (5)
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