Biocompatible Catalysts for Lactide Polymerization—Catalyst Activity, Racemization Effect, and Optimization of the Polymerization Based On Design of Experiments

Agnieszka Gadomska-Gajadhur , Paweł Ruśkowski

Abstract

An original synthesis of Ca, Mg, and Zn 2-ethylhexanoate (octoate) obtained by reaction between metallic powder with 2-ethylhexanoic acid was achieved. The activities of obtaining biocompatible catalysts of lactide polymerization were tested. The most active catalyst was zinc 2-ethylhexanoate (ZnOct2), and the lowest activity catalyst was calcium 2-ethylhexanoate (CaOct2). The ROP process was successfully optimized by using the design of the experiment. Polylactide with Mw = 82.3 kg/mol with lactide conversion up to 85% and 8% content of D-lactic acid has been obtained. Thus, the obtained polylactides can be used in medical and pharmaceutical devices.
Author Agnieszka Gadomska-Gajadhur (FC / CPCT)
Agnieszka Gadomska-Gajadhur,,
- Chair Of Polymer Chemistry And Technology
, Paweł Ruśkowski (FC / CPCT)
Paweł Ruśkowski,,
- Chair Of Polymer Chemistry And Technology
Journal seriesOrganic Process Research & Development, ISSN 1083-6160, e-ISSN 1520-586X
Issue year2020
Vol24
Pages1-8
Publication size in sheets0.5
Keywords in EnglishPLA, racemization, medical devices, DOE, scale-up
ASJC Classification1605 Organic Chemistry; 1606 Physical and Theoretical Chemistry
DOIDOI:10.1021/acs.oprd.0c00149
URL https://pubs.acs.org/doi/10.1021/acs.oprd.0c00149
Languageen angielski
File
acs.oprd.0c00149.pdf 1.8 MB
Score (nominal)100
Score sourcejournalList
ScoreMinisterial score = 100.0, 21-09-2020, ArticleFromJournal
Publication indicators WoS Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2017 = 0.978; WoS Impact Factor: 2018 = 3.327 (2) - 2018=3.171 (5)
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