Biocompatible Catalysts for Lactide Polymerization—Catalyst Activity, Racemization Effect, and Optimization of the Polymerization Based On Design of Experiments
Agnieszka Gadomska-Gajadhur , Paweł Ruśkowski
AbstractAn original synthesis of Ca, Mg, and Zn 2-ethylhexanoate (octoate) obtained by reaction between metallic powder with 2-ethylhexanoic acid was achieved. The activities of obtaining biocompatible catalysts of lactide polymerization were tested. The most active catalyst was zinc 2-ethylhexanoate (ZnOct2), and the lowest activity catalyst was calcium 2-ethylhexanoate (CaOct2). The ROP process was successfully optimized by using the design of the experiment. Polylactide with Mw = 82.3 kg/mol with lactide conversion up to 85% and 8% content of D-lactic acid has been obtained. Thus, the obtained polylactides can be used in medical and pharmaceutical devices.
|Journal series||Organic Process Research & Development, ISSN 1083-6160, e-ISSN 1520-586X|
|Publication size in sheets||0.5|
|Keywords in English||PLA, racemization, medical devices, DOE, scale-up|
|Score||= 100.0, 21-09-2020, ArticleFromJournal|
|Publication indicators||= 0; : 2017 = 0.978; : 2018 = 3.327 (2) - 2018=3.171 (5)|
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