Biological Aggressiveness of Subclinical No-Mass Ductal Carcinoma In Situ (DCIS) Can Be Reflected by the Expression Profiles of EpithelialMesenchymal Transition Triggers

Bartłomiej Szynglarewicz , Piotr Kasprzak , Piotr Donizy , Przemysław Biecek , Agnieszka Halon , Rafal Matkowski

Abstract

Epithelial-mesenchymal transitions (EMTs) have been recently implicated in the process of cancer progression. The aim of this study was to assess how the preoperative expression patterns of EMT biomarkers correlate with the risk of postoperative invasion in ductal carcinoma in situ (DCIS) found on stereotactic breast biopsies. N-cadherin, Snail1, and secreted protein acidic and rich in cysteine (SPARC) immunoreactivity was observed in 8%, 62%, and 38% of tumors, respectively. Snail1 and SPARC expressions were significantly related to N-cadherin expression and to each other. The postoperative upgrading rate was associated with a positive preoperative expression of all biomarkers. Significance of Snail1 and SPARC persisted in multivariate analysis, but the impact of SPARC on invasion was more significant. When these two EMT triggers were considered together, the risk of invasion did not significantly differ between the subtypes of DCIS with single positive expression (SPARC−/Snail1+ vs. SPARC+/Snail1−). However, it was significantly lower in single-positive DCIS when compared to lesions of a double-positive profile (SPARC+/Snail1+). Moreover, there were no cases in the double-negative DCIS (SPARC−/Snail1−), with foci of infiltrating cancer found postoperatively in residual postbiopsy lesions. In contrast, DCIS with a combined high SPARC and Snail1 expression (intermediate or strong) had an invasive component in 66–100% of tumors
Author Bartłomiej Szynglarewicz
Bartłomiej Szynglarewicz,,
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, Piotr Kasprzak
Piotr Kasprzak,,
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, Piotr Donizy
Piotr Donizy,,
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, Przemysław Biecek (FMIS / DCSDCAM)
Przemysław Biecek,,
- Department of CAD/CAM Systems Design and Computer-Aided Medicine
, Agnieszka Halon
Agnieszka Halon,,
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, Rafal Matkowski
Rafal Matkowski,,
-
Journal seriesInternational Journal of Molecular Sciences, ISSN 1422-0067
Issue year2018
Vol19
No12/3941
Pages1-14
Publication size in sheets0.65
Keywords in PolishSnail1, rak piersi
Keywords in Englishductal carcinoma in situ, epithelial-mesenchymal transition, N-cadherin, SPARC, Snail1
ASJC Classification2700 General Medicine; 1312 Molecular Biology; 1503 Catalysis; 1604 Inorganic Chemistry; 1605 Organic Chemistry; 1606 Physical and Theoretical Chemistry; 1607 Spectroscopy; 1706 Computer Science Applications
Abstract in PolishGłównym wynikiem pracy jest badanie korelacji pomiędzy trzema znanymi markerami: N-Cadherin, SPARC i Snail1 w raku piersi. Snail1 jest nowym interesującym markerem oznaczanym i badanym w Dolnośląskim centrum onkologii. W pracy sprawdzaliśmy czy jest on niezależnym markerem od np SPARC czy z nim skorelowanym. Okazuje się że to niezależny marker. Choć dostępna grupa badanych osób nie była powalająco duża i pewnie szersze spojrzenie na ten marker będzie możliwe dopiero po przeprowadzniu meta-analizy.
DOIDOI:10.3390/ijms19123941
URL https://www.mdpi.com/1422-0067/19/12/3941
Languageen angielski
Score (nominal)30
Score sourcejournalList
ScoreMinisterial score = 30.0, 16-06-2020, ArticleFromJournal
Publication indicators WoS Citations = 0; Scopus Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 1.224; WoS Impact Factor: 2018 = 4.183 (2) - 2018=4.331 (5)
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