Biological Aggressiveness of Subclinical No-Mass Ductal Carcinoma In Situ (DCIS) Can Be Reflected by the Expression Profiles of EpithelialMesenchymal Transition Triggers

Przemysław Biecek , Piotr Donizy , Agnieszka Halon , Piotr Kasprzak , Rafal Matkowski , Bartłomiej Szynglarewicz

Abstract

Epithelial-mesenchymal transitions (EMTs) have been recently implicated in the process of cancer progression. The aim of this study was to assess how the preoperative expression patterns of EMT biomarkers correlate with the risk of postoperative invasion in ductal carcinoma in situ (DCIS) found on stereotactic breast biopsies. N-cadherin, Snail1, and secreted protein acidic and rich in cysteine (SPARC) immunoreactivity was observed in 8%, 62%, and 38% of tumors, respectively. Snail1 and SPARC expressions were significantly related to N-cadherin expression and to each other. The postoperative upgrading rate was associated with a positive preoperative expression of all biomarkers. Significance of Snail1 and SPARC persisted in multivariate analysis, but the impact of SPARC on invasion was more significant. When these two EMT triggers were considered together, the risk of invasion did not significantly differ between the subtypes of DCIS with single positive expression (SPARC−/Snail1+ vs. SPARC+/Snail1−). However, it was significantly lower in single-positive DCIS when compared to lesions of a double-positive profile (SPARC+/Snail1+). Moreover, there were no cases in the double-negative DCIS (SPARC−/Snail1−), with foci of infiltrating cancer found postoperatively in residual postbiopsy lesions. In contrast, DCIS with a combined high SPARC and Snail1 expression (intermediate or strong) had an invasive component in 66–100% of tumors
Author Przemysław Biecek (FMIS / DCSDCAM)
Przemysław Biecek,,
- Department of CAD/CAM Systems Design and Computer-Aided Medicine
, Piotr Donizy
Piotr Donizy,,
-
, Agnieszka Halon
Agnieszka Halon,,
-
, Piotr Kasprzak
Piotr Kasprzak,,
-
, Rafal Matkowski
Rafal Matkowski,,
-
, Bartłomiej Szynglarewicz
Bartłomiej Szynglarewicz,,
-
Journal seriesInternational Journal of Molecular Sciences, ISSN 1422-0067, (A 30 pkt)
Issue year2018
Vol19
No12/3941
Pages1-14
Publication size in sheets0.65
Keywords in PolishSnail1, rak piersi
Keywords in Englishductal carcinoma in situ, epithelial-mesenchymal transition, N-cadherin, SPARC, Snail1
ASJC Classification1604 Inorganic Chemistry; 1605 Organic Chemistry; 1606 Physical and Theoretical Chemistry; 1706 Computer Science Applications; 1607 Spectroscopy; 1312 Molecular Biology; 2700 General Medicine; 1503 Catalysis
Abstract in PolishGłównym wynikiem pracy jest badanie korelacji pomiędzy trzema znanymi markerami: N-Cadherin, SPARC i Snail1 w raku piersi. Snail1 jest nowym interesującym markerem oznaczanym i badanym w Dolnośląskim centrum onkologii. W pracy sprawdzaliśmy czy jest on niezależnym markerem od np SPARC czy z nim skorelowanym. Okazuje się że to niezależny marker. Choć dostępna grupa badanych osób nie była powalająco duża i pewnie szersze spojrzenie na ten marker będzie możliwe dopiero po przeprowadzniu meta-analizy.
DOIDOI:10.3390/ijms19123941
URL https://www.mdpi.com/1422-0067/19/12/3941
Languageen angielski
Score (nominal)30
ScoreMinisterial score = 30.0, 04-02-2019, ArticleFromJournal
Ministerial score (2013-2016) = 30.0, 04-02-2019, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2016 = 1.147; WoS Impact Factor: 2017 = 3.687 (2) - 2017=3.878 (5); WoS Citations = 0
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