Steroidy wziewne podawane z nebulizatorów siateczkowych – co powinniśmy wiedzieć?

Tomasz Robert Sosnowski , Marcin Odziomek

Abstract

Inhalation therapy with nebulized steroids (e.g. budesonide) ispossible only if inhaled aerosol droplets contain micronized solidparticles of the active ingredient. Since both aerosol droplets andbudesonide particles have comparable sizes (micrometer-range), itis essential to prove that drug particles are indeed present in theaerosol released from the nebulizer. This work presents data of thestudy focused on the particle size of budesonide in several drugproducts. Particle size determination was done in liquids sampleddirectly from nebulizers (mesh and pneumatic type) during theirnormal operation. It was found that at such conditions the majori-ty of budesonide particles in all tested drugs (Benodil, BudixonNeb, Nebbud, Pulmicort) are smaller than 3-4 μm. Since the ave-rage diameter of droplets (D50, MMAD) in the aerosol releasedfrom studied nebulizers is in the range of 5-6 μm, the results con-firm that in all tested cases the aerosol should contain a similaramount of steroid particles. Small differences in budesonide par-ticle and aerosol droplet size distributions which were found in va-rious nebulizer-drug combinations are unimportant for the predic-ted penetration of aerosolized drugs to the respiratory system.
Author Tomasz Robert Sosnowski (FCPE / CIPE)
Tomasz Robert Sosnowski,,
- Chair of Integrated Process Engineering
, Marcin Odziomek (FCPE / CIPE)
Marcin Odziomek,,
- Chair of Integrated Process Engineering
Other language title versionsInhaled steroids delivered by mesh nebulizers – what should we know?
Journal seriesTerapia, ISSN 1230-3917, (B 5 pkt)
Issue year2019
Vol375
No4
Pages83-88
Publication size in sheets0.5
Keywords in Polishnebulizacja, budezonid, zawiesina, cząstki
Keywords in Englishnebulization, budesonide, liquid suspension, particles
URL https://terapia.com.pl/files/Steroidy%20wziewne%20podawane%20z%20nebulizator%C3%B3w%20siateczkowych%20-%20co%20powinni%C5%9Bmy.pdf
Languagepl polski
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Sosnowski T.R., Odziomek M. - Steroidy wziewne podawane...pdf 452.88 KB
Score (nominal)5
ScoreMinisterial score = 5.0, 08-07-2019, ArticleFromJournal
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UwagiWersja online artykułu została opublikowana w czasopiśmie Terapia: nr 3 (374) - wydanie specjalne, natomiast wersja papierowa została zamieszczona w numerze 4 (375).
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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