A Quantitative Method Using Head Noncontrast CT Scans to Detect Hyperacute Nonvisible Ischemic Changes in Patients With Stroke

Ryszard Gomółka , R.M. Chrzan , Andrzej Urbanik , W.L. Nowiński

Abstract

PURPOSE: Because clinical evaluation of noncontrast computed tomography (CT) has a poor sensitivity in the evaluation of acute ischemic stroke, computer-aided diagnosis may be able to facilitate the performance. Recently, we introduced a computational method for the detection and localization of visible infarcts. Herein, we aimed to evaluate and extend a previous method, the Stroke Imaging Marker (SIM), to localize nonvisible hyperacute ischemia. MATERIALS AND METHODS: On the basis of the SIM and its components-the ratio of percentile differences in subranges of Hounsfield Unit (HU) distribution (P-ratio), ratio of voxels count in ranges of brain CT intensity, median HU attenuation value-the infarct localization was performed in 140 early and follow-up scans of 70 patients. In none of the early scans was the infarct visible to a radiologist or an experienced stroke neuroradiologist. The infarcted hemisphere detection rate (HDR) and sensitivity of infarct localization were measured by overlapping the region of detected tissue in the initial scan, with the gold standard set for the fully visible stroke in the follow-up scan. RESULTS: The best performance of the algorithm was found for the P-ratio including seven percentile subranges within the range of 35th-75th percentile. The modified SIM provided a 76% ischemic HDR and 54% sensitivity in spatial localization of hyperacute ischemia (68% among properly detected infarct sides). CONCLUSION: The improved SIM is a dedicated and potentially useful tool for hyperacute nonvisible brain infarct detection from CT scans and may contribute to reduction of image-to-needle time in patients eligible for revascularization therapy.
Author Ryszard Gomółka ISE
Ryszard Gomółka,,
- The Institute of Electronic Systems
, R.M. Chrzan
R.M. Chrzan,,
-
, Andrzej Urbanik
Andrzej Urbanik,,
-
, W.L. Nowiński
W.L. Nowiński,,
-
Journal seriesJournal of Neuroimaging, ISSN 1051-2284
Issue year2016
Vol26
No6
Pages581-587
Publication size in sheets0.5
Keywords in EnglishNCCT; Stroke; computer-aided diagnosis; rt-PA; stroke imaging marker
DOIDOI:10.1111/jon.12363
URL https://www.ncbi.nlm.nih.gov/pubmed/27238914
projectResearch on measurement, circuit and signal theory and electronic circuits and systems. Project leader: Starecki Tomasz, , Phone: +48 22 825 37 09; 22 234 7744; +48 22 234 3657, start date 12-05-2016, end date 31-12-2017, ISE/2016/DS, Completed
WEiTI Działalność statutowa
Languageen angielski
Score (nominal)20
ScoreMinisterial score = 20.0, 27-03-2017, ArticleFromJournal
Ministerial score (2013-2016) = 20.0, 27-03-2017, ArticleFromJournal
Publication indicators WoS Impact Factor: 2016 = 1.664 (2) - 2016=1.637 (5)
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