Resolution of racemic 1-azido-3-aryloxy-2-propanols by lipase-catalyzed enantioselective acetylation
Beata Krystyna Pchelka , André Loupy , Jan Plenkiewicz , Luis Blanco
AbstractKinetic resolution of racemic 1-azido-3-aryloxy-2-propanols 1a–g was performed using supported lipase of Candida antarctica-B (Novozym® SP 435) in toluene at 4°C with isopropenyl acetate as the acyl donor to afford the optically active (S)-alcohols 2a–g and their corresponding (R)-acetates 3a–g with E values from 56 to 72.
|Journal series||Tetrahedron-Asymmetry, ISSN 0957-4166|
|Publication indicators||: 2006 = 2.468 (2) - 2007=2.46 (5)|
|Citation count*||32 (2013-01-30)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.