Antimicrobial films of poly(2-aminoethyl methacrylate) and its copolymers doped with TiO2 and CaCO3

Kamil Wojciechowski , Małgorzata Gutarowicz , Jolanta Mierzejewska , Paweł Parzuchowski

Abstract

Polymeric coatings with positive surface charge offer potential antimicrobial activity, which they owe to a simple electrostatic attraction with negatively charged bacterial walls and membranes. We describe synthesis and characterization of poly(2-aminoethyl methacrylate) and its copolymers with methyl methacrylate and butyl acrylate, as potential binders for antimicrobial solvent-cast paints. TiO2 and CaCO3 mineral particles were employed as model pigments/fillers, as they are used in most real-life paint formulations. Electrokinetic (ζ) potential and antimicrobial activity of thin films made of the (co)polymers in the absence and presence of TiO2 and CaCO3 nanopowders were assessed using streaming current measurements and microbial growth inhibition tests, respectively. Independently of the structure of the monomers used for the synthesis, the films showed positive ζ-potential values (up to +95 mV) in the pH range 3.5-8.0. The presence of mineral particles at 50% dry weight of the films did not affect significantly the ζ(pH) curves. The films made of the mixed dispersions remained positively charged and inhibited growth of both Gram-negative (E. coli) and Gram-positive (S. aureus) bacteria, as well as yeast (C. albicans). The mixed polymeric-mineral films described in this study seem to be promising potential candidates for designing antimicrobial coatings aimed to prevent spreading of bacterial infections.

Author Kamil Wojciechowski (FC / CMB)
Kamil Wojciechowski,,
- Chair of Medical Biotechnology
, Małgorzata Gutarowicz (WUT)
Małgorzata Gutarowicz,,
- Warsaw University of Technology
, Jolanta Mierzejewska (FC / CDSB)
Jolanta Mierzejewska,,
- Chair of Drug and Cosmetics Biotechnology
, Paweł Parzuchowski (FC / CPCT)
Paweł Parzuchowski,,
- Chair Of Polymer Chemistry And Technology
Journal seriesColloids and Surfaces B-Biointerfaces, [Colloids and Surfaces B: Biointerfaces], ISSN 0927-7765, e-ISSN 1873-4367
Issue year2020
Vol185
Pages1-8
Publication size in sheets0.5
Article number110605
Keywords in EnglishPolymer, Gram-positive, Gram-negative, Titania, Paint, Antibacterial
ASJC Classification2700 General Medicine; 1305 Biotechnology; 1505 Colloid and Surface Chemistry; 1606 Physical and Theoretical Chemistry; 3110 Surfaces and Interfaces
DOIDOI:10.1016/j.colsurfb.2019.110605
URL https://www.sciencedirect.com/science/article/pii/S0927776519307490
Languageen angielski
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wdpb_publikacje_pliki_plik_publikacja_3862_org.pdf 952.67 KB
Score (nominal)100
Score sourcejournalList
ScoreMinisterial score = 100.0, 01-07-2020, ArticleFromJournal
Publication indicators Scopus Citations = 1; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 1.042; WoS Impact Factor: 2018 = 3.973 (2) - 2018=4.18 (5)
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