A blood pool contrast aided T1 functional MRI in patients with brain tumors—a preliminary study

Agata Majos , Tomasz Wolak , Piotr Bogorodzki , Krzysztof Tybor , Michał Sapieha , Ludomir Stefańczyk

Abstract

Introduction The aim of our study was to determine the possibility of using a new functional technique: a T1-dependent sequence with administration of blood pool contrast agent (BPCA), in patients with brain tumors before and after surgical treatment. We also aimed to compare our results with those obtained using the fMRI technique, based on Blood Oxygenation Level-Dependent (BOLD) contrast. Methods For each of our 14 oncologic patients (four before and ten after neurosurgical intervention), we obtained: a T1-3D GRE sequence (TR = 2.6 ms/TE = 1.1 ms/FA = 10°) after intravenous administration of BPCA (0.03 mmol/kg), as well as a T2*EPI sequence (TR = 3 s/TE = 50 ms/FA = 90°). Movement and/or tactile block type paradigms were carried out during both functional runs. SPM5 software was used for analysis. Results For both functional techniques, maximum activations were localized in the same areas. There were no significant differences observed in the t values calculated for activations located in the primary motor cortex between groups of pre- and post-intervention patients (in the same functional technique). The mean values for T2* EPI examinations were 10.84 and 9.36, respectively. The mean t values for the T1 technique were lower, especially for the post-intervention patients (5.83 and 3.9, respectively). Conclusions The T1 technique can be used to detect functional areas in patients with brain tumors, pre-, and post-surgical intervention. This technique enables the evaluation of cortical centers that suffer from susceptibility artifacts when using the T2* BOLD technique. Activations found using both techniques have the same localization, with lower values for the T1 technique.
Author Agata Majos - [Medical University of Lodz]
Agata Majos,,
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, Tomasz Wolak (FEIT / RE)
Tomasz Wolak,,
- The Institute of Radioelectronics
, Piotr Bogorodzki (FEIT / RE)
Piotr Bogorodzki,,
- The Institute of Radioelectronics
, Krzysztof Tybor - [Medical University of Lodz]
Krzysztof Tybor,,
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, Michał Sapieha - [Medical University of Lodz]
Michał Sapieha,,
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, Ludomir Stefańczyk - [Medical University of Lodz]
Ludomir Stefańczyk,,
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Journal seriesNeuroradiology, ISSN 0028-3940, (A 30 pkt)
Issue year2011
Vol53
No7
Pages523-531
Keywords in EnglishBrain tumors, CBV, Contrast media, Functional MRI, Imaging / Radiology, Neurology, Neuroradiology, Neurosciences, Neurosurgery
ASJC Classification2705 Cardiology and Cardiovascular Medicine; 2728 Clinical Neurology; 2741 Radiology Nuclear Medicine and imaging
DOIDOI:10.1007/s00234-010-0809-z
URL http://link.springer.com/article/10.1007/s00234-010-0809-z
Languageen angielski
Score (nominal)30
Score sourcejournalList
Publication indicators WoS Citations = 2; Scopus Citations = 2; Scopus SNIP (Source Normalised Impact per Paper): 2014 = 1.424; WoS Impact Factor: 2011 = 2.824 (2) - 2011=2.796 (5)
Citation count*3 (2020-01-11)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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