Effect of 2-Hydroxypropyl-β-cyclodextrin on Solubility of Sparingly Soluble Drug Derivatives of Anthranilic Acid

Urszula Domańska-Żelazna , Aleksandra Pelczarska , Aneta Pobudkowska-Mirecka


International Journal of Molecular Sciences, an international, peer-reviewed Open Access journal., Guest-host complex formation of three drug derivatives of anthranilic acid, mefenamic acid, niflumic acid, and flufenamic acid with 2-hydroxypropyl-β-cyclodextrin (2HP-β-CD) in aqueous solutions was investigated using “Phase solubility study” with UV-vis spectrophotometry. Solubility of sparingly soluble drugs has been improved by addition of 2HP-β-CD at two temperatures 298.15 K and 310.15 K and two pH values 2 and 7. The influence of different 2HP-β-CD concentration on solubility of drugs at different pH and temperatures has been investigated. The 2HP-β-CD-drug complex stability constants (Ks), and dissociations constants (Kd), as well as the thermodynamic parameters of reaction, i.e., the free energy change (ΔG), the enthalpy change (ΔH) and the entropy change (ΔS), were determined. The experimental data indicated formation of 1:1 inclusion complexes, which were found effective binders increasing the solubility of drugs.
Author Urszula Domańska-Żelazna ZChF
Urszula Domańska-Żelazna,,
- Department Of Physical Chemistry
, Aleksandra Pelczarska ZChF
Aleksandra Pelczarska,,
- Department Of Physical Chemistry
, Aneta Pobudkowska-Mirecka ZChF
Aneta Pobudkowska-Mirecka,,
- Department Of Physical Chemistry
Journal seriesInternational Journal of Molecular Sciences, ISSN 1422-0067
Issue year2011
Keywords in English2-hydroxypropyl-\\textless\em\\textgreater\β\\textless\/em\\textgreater\-cyclodextrin, Experimental solubility, solubility enhancement, thermodynamics of complex formation
URL http://www.mdpi.com/1422-0067/12/4/2383
Languageen angielski
ijms-12-02383.pdf 436.09 KB
Score (nominal)30
Publication indicators WoS Impact Factor: 2016 = 3.226 (2) - 2016=3.482 (5)
Citation count*2 (2013-01-30)
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