Effect of 2-Hydroxypropyl-β-cyclodextrin on Solubility of Sparingly Soluble Drug Derivatives of Anthranilic Acid

Urszula Domańska-Żelazna , Aleksandra Pelczarska , Aneta Pobudkowska-Mirecka

Abstract

International Journal of Molecular Sciences, an international, peer-reviewed Open Access journal., Guest-host complex formation of three drug derivatives of anthranilic acid, mefenamic acid, niflumic acid, and flufenamic acid with 2-hydroxypropyl-β-cyclodextrin (2HP-β-CD) in aqueous solutions was investigated using “Phase solubility study” with UV-vis spectrophotometry. Solubility of sparingly soluble drugs has been improved by addition of 2HP-β-CD at two temperatures 298.15 K and 310.15 K and two pH values 2 and 7. The influence of different 2HP-β-CD concentration on solubility of drugs at different pH and temperatures has been investigated. The 2HP-β-CD-drug complex stability constants (Ks), and dissociations constants (Kd), as well as the thermodynamic parameters of reaction, i.e., the free energy change (ΔG), the enthalpy change (ΔH) and the entropy change (ΔS), were determined. The experimental data indicated formation of 1:1 inclusion complexes, which were found effective binders increasing the solubility of drugs.
Author Urszula Domańska-Żelazna (FC / DPC)
Urszula Domańska-Żelazna,,
- Department Of Physical Chemistry
, Aleksandra Pelczarska (FC / DPC)
Aleksandra Pelczarska,,
- Department Of Physical Chemistry
, Aneta Pobudkowska-Mirecka (FC / DPC)
Aneta Pobudkowska-Mirecka,,
- Department Of Physical Chemistry
Journal seriesInternational Journal of Molecular Sciences, ISSN 1422-0067, (A 30 pkt)
Issue year2011
Vol12
No4
Pages2383-2394
Keywords in English2-hydroxypropyl-\\textless\em\\textgreater\β\\textless\/em\\textgreater\-cyclodextrin, Experimental solubility, solubility enhancement, thermodynamics of complex formation
ASJC Classification1604 Inorganic Chemistry; 1605 Organic Chemistry; 1606 Physical and Theoretical Chemistry; 1706 Computer Science Applications; 1607 Spectroscopy; 1312 Molecular Biology; 2700 General Medicine; 1503 Catalysis
DOIDOI:10.3390/ijms12042383
URL http://www.mdpi.com/1422-0067/12/4/2383
Languageen angielski
File
ijms-12-02383.pdf 436.09 KB
Score (nominal)30
Score sourcejournalList
Publication indicators Scopus Citations = 15; GS Citations = 2.0; Scopus SNIP (Source Normalised Impact per Paper): 2011 = 1.195; WoS Impact Factor: 2012 = 2.464 (2) - 2012=2.732 (5)
Citation count*2 (2013-01-30)
Cite
Share Share

Get link to the record


* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
Back
Confirmation
Are you sure?