Effect of 2-Hydroxypropyl-β-cyclodextrin on Solubility of Sparingly Soluble Drug Derivatives of Anthranilic Acid
Urszula Domańska-Żelazna , Aleksandra Pelczarska , Aneta Pobudkowska-Mirecka
AbstractInternational Journal of Molecular Sciences, an international, peer-reviewed Open Access journal., Guest-host complex formation of three drug derivatives of anthranilic acid, mefenamic acid, niflumic acid, and flufenamic acid with 2-hydroxypropyl-β-cyclodextrin (2HP-β-CD) in aqueous solutions was investigated using “Phase solubility study” with UV-vis spectrophotometry. Solubility of sparingly soluble drugs has been improved by addition of 2HP-β-CD at two temperatures 298.15 K and 310.15 K and two pH values 2 and 7. The influence of different 2HP-β-CD concentration on solubility of drugs at different pH and temperatures has been investigated. The 2HP-β-CD-drug complex stability constants (Ks), and dissociations constants (Kd), as well as the thermodynamic parameters of reaction, i.e., the free energy change (ΔG), the enthalpy change (ΔH) and the entropy change (ΔS), were determined. The experimental data indicated formation of 1:1 inclusion complexes, which were found effective binders increasing the solubility of drugs.
|Journal series||International Journal of Molecular Sciences, ISSN 1422-0067, (A 30 pkt)|
|Keywords in English||2-hydroxypropyl-\\textless\em\\textgreater\β\\textless\/em\\textgreater\-cyclodextrin, Experimental solubility, solubility enhancement, thermodynamics of complex formation|
|ASJC Classification||; ; ; ; ; ; ;|
|Publication indicators||= 15; = 2.0; : 2011 = 1.195; : 2012 = 2.464 (2) - 2012=2.732 (5)|
|Citation count*||2 (2013-01-30)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.