In vitro assessment of antibacterial properties and cytotoxicity of Al2O3‐Ag nanopowders

A M Jastrzębska , E Radziun , M Rosłon , A R Kunicki , A R Olszyna , J Dudkiewicz-Wilczyńska , E Anuszewska , Ewa Karwowska

Abstract

AbstractThe present paper describes an In vitro assessment of the antibacterial properties and cytotoxic activity on mammalian cells of silver nanoparticles incorporated into an aluminium nano-oxide substrate produced by the thermal decomposition?reduction method. The Al2O3?Ag nanopowders show good bactericidal and fungicidal properties. An Al2O3?Ag (12·55 wt-\%) specimen at the concentration of 50 mg mL?1 reduced considerably the populations of Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus and Bacillus subtilis species, whereas the same nanopowder in a concentration of 90 mg mL?1 inhibited significantly the growth of P. aeruginosa, E. coli, S. aureus and Candida albicans and also significantly limited the number of B. subtilis. The Al2O3?Ag nanoparticles also showed no cytotoxic effects on the three selected cell lines, i.e. L929, BJ and HeLa, and the cells remained \\textgreater\75\% viability, as measured by MTT assay, and \\textgreater\102\% viability, obtained by EZ4U assay, relative to control at concentration as high as 200 ?g mL?1.
Author A M Jastrzębska - [Politechnika Warszawska]
A M Jastrzębska,,
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, E Radziun - [National Medicines Institute, Warsaw]
E Radziun,,
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, M Rosłon - [National Medicines Institute, Warsaw]
M Rosłon,,
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, A R Kunicki - [Warsaw University of Technology (PW), MNiSW [80]]
A R Kunicki,,
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- Politechnika Warszawska
, A R Olszyna - [Politechnika Warszawska]
A R Olszyna,,
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, J Dudkiewicz-Wilczyńska - [National Medicines Institute, Warsaw]
J Dudkiewicz-Wilczyńska,,
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, E Anuszewska - [National Medicines Institute, Warsaw]
E Anuszewska,,
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, Ewa Karwowska (FEE / DB)
Ewa Karwowska,,
- Department of Biology
Journal seriesAdvances in Applied Ceramics, ISSN 1743-6753, (A 30 pkt)
Issue year2011
Vol110
No6
Pages353-359
Keywords in EnglishAntibacterial, Cytotoxicity, Nanoalumina, Nanoparticles, Nanopowder, Nanosilver
ASJC Classification2209 Industrial and Manufacturing Engineering; 2503 Ceramics and Composites
DOIDOI:10.1179/1743676111Y.0000000023
Languageen angielski
Score (nominal)30
Score sourcejournalList
Publication indicators Scopus Citations = 22; WoS Citations = 22; Scopus SNIP (Source Normalised Impact per Paper): 2011 = 0.83; WoS Impact Factor: 2011 = 0.871 (2) - 2011=1.022 (5)
Citation count*25 (2020-01-20)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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