Interactions of carbon nanotubes and carbon nanohorns with a model membrane layer and lung surfactant in vitro

Dorota Kondej , Tomasz Robert Sosnowski

Abstract

A broader use of carbon nanomaterials increases the risk of their inhalation as aerosol dispersed in the air. Inhaled nanometer-sized particles are known to penetrate to the pulmonary region where they interact with the lung surfactant as the first barrier they meet and eventually penetrate to the surface of the cellular layer. This study presents the results of experimental studies of physicochemical interactions between several types of carbon nanomaterials (nanotubes and nanohorns of various size and surface properties) and lipid layers in two qualitatively different experimental systems: Langmuir trough and pulsated drop tensiometer, both providing complementary possibilities to study interfacial properties of the lipid-rich layer. Quantified alterations in mechanical properties if lipid films (equilibrium compressibility, dynamic surface elasticity, and viscosity) indicate that nanocarbons with different wettability may induce concentration-dependent frustration of the lung surfactant and biological membranes in vivo. The observed effects are discussed not only in relation to health effects from nanoparticle inhalation but also to potential medical applications of engineered carbon nanomaterials.
Author Dorota Kondej - Centralny Instytut Ochrony Pracy - Państwowy Instytut Badawczy (CIOP PIB) [Centralny Instytut Ochrony Pracy - Państwowy Instytut Badawczy (CIOP PIB)]
Dorota Kondej,,
-
- Centralny Instytut Ochrony Pracy - Państwowy Instytut Badawczy
, Tomasz Robert Sosnowski (FCPE / CIPE)
Tomasz Robert Sosnowski,,
- Chair of Integrated Process Engineering
Journal seriesJournal of Nanomaterials, ISSN 1687-4110
Issue year2019
Vol2019
Pages1-10
Publication size in sheets0.5
Article number9457683
ASJC Classification2500 General Materials Science
DOIDOI:10.1155/2019/9457683
URL https://www.hindawi.com/journals/jnm/2019/9457683/
Languageen angielski
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Kondej D., Sosnowski T.R. - Interactions of carbon....pdf of 11-02-2019
2.99 MB
Score (nominal)70
Score sourcejournalList
ScoreMinisterial score = 70.0, 10-06-2020, ArticleFromJournal
Publication indicators Scopus Citations = 1; WoS Citations = 1; GS Citations = 1.0; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 0.6; WoS Impact Factor: 2018 = 2.233 (2) - 2018=2.308 (5)
Citation count*1 (2020-07-13)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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