Ultralow anterior resection with implantation of gentamicin-collagen sponge and no defunctioning stoma: anastomotic leakage and local cancer relapse
Tomasz Michalik , Rafał Matkowski , Przemysław Biecek , Jozef Forgacz , Bartlomiej Szynglarewicz
AbstractBackgroundAnterior resection with total mesorectal excision (TME) of ultralow rectal cancer may result in the increased risk of the anastomotic leakage (AL). The aim of this study was to evaluate the usefulness of the gentamicin-collagen sponge (GCS) for the protection against symptomatic AL and investigate association between AL and local relapse (LR).Patients and methodsA series of 158 patients with ultralow rectal cancer was studied. All the patients underwent R0 sphincter-saving TME with anastomosis wrapping using GCS. In none of the cases a temporary protective stoma was constructed.ResultsAL rate was 3.2% (5/158) while median time to AL diagnosis was 5 days following surgery (range 3-15). There was no postoperative and leakage-related mortality. Patient age > 75 years and smoking were independent risk factors related to significantly increased AL rate: 12.5%vs. 0.8% (P= 0.0004) and 5.7%vs. 0%P= 0.043), respectively. LR was observed in 12% of cases. It was highly significantly more common and developed earlier in patients who have had AL when compared with non-AL group: 80%vs. 9% (P= 0.00001) and 8.5vs. 17 months (P= 0.014), respectively.ConclusionsAnastomosis wrapping with GCS after anterior resection with TME is a safe procedure resulting in the low incidence of anastomotic leakage which may be also associated with decreased risk of local relapse.
|Journal series||Radiology and Oncology, ISSN 1318-2099, e-ISSN 1581-3207|
|Publication size in sheets||0.5|
|Keywords in Polish||rak odbytu, analiza danych|
|Keywords in English||anastomotic leakage; anterior resection; gentamicin-collagen sponge; rectal cancer; total mesorectal excision|
|Abstract in Polish||Analiza danych dotyczących operowalnego nowotworu. Budowa modelu predykcyjnego i eksploracyjna analiza danych|
|Score||= 70.0, 30-01-2020, ArticleFromJournal|
|Publication indicators||= 0; : 2017 = 0.814; : 2018 = 1.846 (2) - 2018=1.923 (5)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.