Hydrophilic quaternary ammonium ionenes - Is there an influence of backbone flexibility and topology on antibacterial properties?
Rafał Kopiasz , Waldemar Tomaszewski , Aleksandra Kuźmińska , Karolina Chreptowicz , Jolanta Mierzejewska , Tomasz Ciach , Dominik Jańczewski
The antimicrobial properties of polycations are strongly affected by the structural features such as the backbone flexibility and topology (isomerism) through the polymer ability to attain proper conformation in interaction with the cell membrane. In this paper, a synthesis and biocidal properties evaluation of ionenes characterized by different backbone topology (isomerism) and flexibility are presented. The findings reveal influence of variation in topology on activity against different microorganisms, and general positive effect of improved flexibility. Furthermore, one of the obtained ionenes displays degradable properties in near physiological environment (phosphate-buffered saline pH 7.4, 37 °C). The degradation proceeds via Hofmann elimination reaction and the products are not of acidic character. For the first time a new class of degradable ionenes with a high antimicrobial potential is presented.
|Journal series||Macromolecular Bioscience, ISSN 1616-5187, e-ISSN 1616-5195|
|Publication size in sheets||0.5|
|Keywords in English||antimicrobial activity, ionene, polyaddition, polycation, quaternary ammonium compounds|
|ASJC Classification||; ; ; ;|
|Score||= 100.0, 17-08-2020, ArticleFromJournal|
|Publication indicators||= 0; = 0; : 2017 = 0.776; : 2018 = 2.895 (2) - 2018=3.112 (5)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.