Study on optimization of nano-coatings for ultra-sensitive biosensors based on long-period fiber grating

Sankhyabrata Bandyopadhyay , Liyang Shao , Chao Wang , Liu Shuaiqi , Q. Wu , Guoqiang Gu , Jie Hu , Yanjun Liu , Chen Xiaolong , Zhangqi Song , Xuefeng Song , Qiaoliang Bao , Mateusz Jakub Śmietana

Abstract

Bio-chemical sensors are expected to offer high sensitivity and specificity towards the detection of an analyte. It has been found that optical sensors based on long period fiber gratings (LPFGs) meet most of these requirements, particularly when coated with thin and high-refractive index overlays with proper bio-functionalization. In this paper, the influence of properties of the overlay material on the sensitivity of LPFG sensors to bio-analytes is analyzed. It has been observed that the sensitivity of a particular cladding mode of LPFG can be changed drastically with the adhesion of few tens of ‘nm’ of bio-layers to the surface of LPFG. “Volume refractive index sensitivity” and “add-layer sensitivity” of a particular cladding mode, dynamic range, and limit of detection of the sensors have been investigated in the context of overlay materials, bio-functionalization steps, and surrounding buffer medium. The selection criteria of the thin-film deposition technique are discussed with the aim of designing highly sensitive sensors for biological and chemical applications. Concept of optimum overlay thickness has been redefined and an effective case-specific design methodology is proposed.
Author Sankhyabrata Bandyopadhyay
Sankhyabrata Bandyopadhyay,,
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, Liyang Shao
Liyang Shao,,
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, Chao Wang
Chao Wang,,
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, Liu Shuaiqi
Liu Shuaiqi,,
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, Q. Wu
Q. Wu,,
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, Guoqiang Gu
Guoqiang Gu,,
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, Jie Hu
Jie Hu,,
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, Yanjun Liu
Yanjun Liu,,
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, Chen Xiaolong - National Institute for Materials Science Tsukuba (NIMS)
Chen Xiaolong,,
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, Zhangqi Song
Zhangqi Song,,
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et al.`
Journal seriesSensing and Bio-Sensing Research, ISSN , e-ISSN 2214-1804
Issue year2020
Vol27
NoFebruary 2020
Pages1-11
Publication size in sheets0.5
Article number100320
ASJC Classification1305 Biotechnology; 1711 Signal Processing; 2208 Electrical and Electronic Engineering; 2504 Electronic, Optical and Magnetic Materials
DOIDOI:10.1016/j.sbsr.2019.100320
URL https://www.sciencedirect.com/science/article/pii/S221418041930128X?via%3Dihub
ProjectDIAMSEC-ultra-sensitive sensory platform for rapid detection of epidemiological and pandemic threats. Project leader: Śmietana Mateusz Jakub, , Phone: (22) 234 63 64, application date 04-11-2016, start date 01-06-2017, planned end date 31-05-2020, MO/2016/7, Implemented
WEiTI Projects financed by NCRD [Projekty finansowane przez NCBiR (NCBR)]
Languageen angielski
Score (nominal)70
Score sourcejournalList
ScoreMinisterial score = 70.0, 14-09-2020, ArticleFromJournal
Publication indicators Scopus Citations = 1; WoS Citations = 1; Scopus SNIP (Source Normalised Impact per Paper): 2018 = 1.012
Citation count*2 (2020-09-22)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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