A simple, low-cost and green method for controlling the cytotoxicity of MXenes

Anita Rozmysłowska-Wojciechowska , Aleksandra Szuplewska , Tomasz Wojciechowski , Szymon Poźniak , Joanna Mitrzak , Michał Chudy , Wanda Ziemkowska , Leszek Chlubny , Andrzej Olszyna , Agnieszka Jastrzębska

Abstract

MXene phases are a member of the intriguing 2D material family, beyond graphene. They are good candidates for many applications, however, their potential toxicity is of crucial importance for future development. Herein, we present a simple, low-cost and fully green approach for controlling the potential cytotoxicity of 2D MXenes after delamination by harnessing the interactions that occur between the surface of MXene phases and natural biomacromolecule – collagen. We also demonstrate that the step-by-step adsorption and desorption of collagen from the surface of 2D MXenes is easily controlled using in situ zeta potential measurements coupled with dynamic light scattering (DLS) method. The obtained results demonstrated that the electrostatically driven unprecedented susceptibility of the MXenes' surfaces to collagen. Surface-modification reduces toxicity of MXenes in vitro i.e. adjust cells' viabilities as well as reduce their oxidative stress. This indicates enhanced biocompatibility of 2D Ti3C2 and Ti2C MXenes surface-modified with collagen, which is involved in many bio-interactions as important building blocks in the human body. The presented study opens new avenues for designing MXenes with defined surface properties and paves the way for their future successful management in nano-medicinal applications.

Author Anita Rozmysłowska-Wojciechowska (FMSE / DSMP)
Anita Rozmysłowska-Wojciechowska,,
- Division of Ceramic Materials and Polymers
, Aleksandra Szuplewska (FC / CMB)
Aleksandra Szuplewska,,
- Chair of Medical Biotechnology
, Tomasz Wojciechowski (FC / DCOC)
Tomasz Wojciechowski,,
- Department Of Catalysis And Organometallic Chemistry
, Szymon Poźniak (FMSE / DSMP)
Szymon Poźniak,,
- Division of Ceramic Materials and Polymers
, Joanna Mitrzak (WUT)
Joanna Mitrzak,,
- Warsaw University of Technology
, Michał Chudy (FC / CMB)
Michał Chudy,,
- Chair of Medical Biotechnology
, Wanda Ziemkowska (FC / DCOC)
Wanda Ziemkowska,,
- Department Of Catalysis And Organometallic Chemistry
, Leszek Chlubny - AGH University of Science and Technology (AGH) [AGH University of Science and Technology (AGH)]
Leszek Chlubny,,
-
- Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie
, Andrzej Olszyna (FMSE / DSMP)
Andrzej Olszyna,,
- Division of Ceramic Materials and Polymers
, Agnieszka Jastrzębska (FMSE / DSMP)
Agnieszka Jastrzębska,,
- Division of Ceramic Materials and Polymers
Journal seriesMaterials Science & Engineering C - Materials for Biological Applications, [Materials Science and Engineering C], ISSN 0928-4931, e-ISSN 1873-0191
Issue year2020
Vol111
Pages1-8
Publication size in sheets0.5
Keywords in EnglishTi3C2; Ti2C; MXenes; Collagen; Zeta potential; Biological activity
ASJC Classification2210 Mechanical Engineering; 2211 Mechanics of Materials; 2500 General Materials Science; 3104 Condensed Matter Physics
DOIDOI:10.1016/j.msec.2020.110790
URL https://www.sciencedirect.com/science/article/pii/S0928493119333132#!
Languageen angielski
Additional file
1-s2.0-S0928493119333132-main.pdf 6.71 MB
Score (nominal)140
Score sourcejournalList
ScoreMinisterial score = 140.0, 24-09-2020, ArticleFromJournal
Publication indicators Scopus Citations = 2; GS Citations = 2.0; WoS Citations = 2; Scopus SNIP (Source Normalised Impact per Paper): 2017 = 1.384; WoS Impact Factor: 2018 = 4.959 (2) - 2018=4.708 (5)
Citation count*2 (2020-09-02)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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