Elemental speciation analysis in biochemistry by electrospray mass spectrometry
Hubert Chassaigne , Véronique Vacchina , Ryszard Łobiński
AbstractThe recent advances and trends in the development and applications of electrospray mass spectrometry (ESI-MS) to speciation analysis are highlighted. The use of the different operational modes of ESI-MS: elemental mode (source collision-induced dissociation (SCID)), molecular mode (MS of protonated molecule ions) and tandem MS mode (product ion scan of the collision-induced dissociation (CID) products of the protonated molecule ion), is discussed. Advantages and limitations of ESI-MS for signal identification in high performance liquid chromatography (HPLC)–ICP-MS and as a free-standing tool for species-selective analysis are highlighted. The discussion is illustrated with a number of examples related to the trace element speciation in biochemistry, viz. selenium in yeast, arsenic in seaweeds, cobalamins in pharmaceutical preparations, and Cd complexes with phytochelatins and metallothioneins in plant and animal tissues
|Journal series||Trac-Trends in Analytical Chemistry, ISSN 0165-9936|
|Keywords in English||Arsenic, Cobalamin, Electrospray mass spectrometry, Metallothionein, Phytochelatin, Selenium, Speciation|
|Publication indicators||= 54; : 2000 = 1.42; : 2006 = 5.068 (2) - 2007=5.894 (5)|
|Citation count*||66 (2015-02-27)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.