Identification of dimethylarsinoyl-riboside derivatives in seaweed by pneumatically assisted electrospray tandem mass spectrometry

Shona McSheehy , Marek Marcinek , Hubert Chassaigne , Joanna Szpunar


Pneumatically-assisted electrospray tandem mass spectrometry (ES MS/MS) was proposed as a technique for the identification of dimethylarsinoyl-riboside derivatives (arsenosugars) in seaweed (Laminaria). Conditions for the acquisition of MS and MS/MS spectra were optimized. A size-exclusion HPLC (SE HPLC) step was developed for the purification of algal extracts prior to ES MS. The arsenosugar fraction was found to elute prior to the majority of other arsenic compounds. The identity of the compounds expected to be arsenosugar compounds was confirmed by the collision induced dissociation (CID) of the relevant protonated molecule ions. An independent confirmation of the identity of analytes was obtained by two-dimensional (size-exclusion–anion exchange) HPLC–ICP MS with signal identification by spiking with the appropriate arsenosugar standards.
Author Shona McSheehy
Shona McSheehy,,
, Marek Marcinek (FC / CICSST)
Marek Marcinek,,
- Chair Of Inorganic Chemistry And Solid State Technology
, Hubert Chassaigne
Hubert Chassaigne,,
, Joanna Szpunar
Joanna Szpunar,,
Journal seriesAnalytica Chimica Acta, ISSN 0003-2670
Issue year2000
Keywords in Englishalgae, Arsenosugars, ES MS/MS, HPLC–ICP MS, Speciation
ASJC Classification1607 Spectroscopy; 2304 Environmental Chemistry; 1303 Biochemistry; 1602 Analytical Chemistry
Score (nominal)40
Score sourcejournalList
Publication indicators WoS Citations = 53; GS Citations = 64.0; Scopus SNIP (Source Normalised Impact per Paper): 2000 = 1.158; WoS Impact Factor: 2006 = 2.894 (2) - 2007=3.348 (5)
Citation count*64 (2015-03-26)
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