Attraction and repulsion of spiral waves by inhomogeneity of conduction anisotropy—a model of spiral wave interaction with electrical remodeling of heart tissue

Pawel Kuklik , Prashanthan Sanders , Lukasz Szumowski , Jan Żebrowski

Abstract

Various forms of heart disease are associated with remodeling of the heart muscle, which results in a perturbation of cell-to-cell electrical coupling. These perturbations may alter the trajectory of spiral wave drift in the heart muscle. We investigate the effect of spatially extended inhomogeneity of transverse cell coupling on the spiral wave trajectory using a simple active media model. The spiral wave was either attracted or repelled from the center of inhomogeneity as a function of cell excitability and gradient of the cell coupling. High levels of excitability resulted in an attraction of the wave to the center of inhomogeneity, whereas low levels resulted in an escape and termination of the spiral wave. The spiral wave drift velocity was related to the gradient of the coupling and the initial position of the wave. In a diseased heart, a region of altered transverse coupling corresponds with local gap junction remodeling that may be responsible for stabilization-destabilization of spiral waves and hence reflect potentially important targets in the treatment of heart arrhythmias.
Author Pawel Kuklik - [The University of Adelaide]
Pawel Kuklik,,
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, Prashanthan Sanders - [The University of Adelaide]
Prashanthan Sanders,,
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, Lukasz Szumowski - [Instytut Kardiologii im. Prymasa Tysiaclecia Stefana Kardynala Wyszynskiego]
Lukasz Szumowski,,
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, Jan Żebrowski (FP / PCSD)
Jan Żebrowski,,
- Physics of Complex Systems Divison
Journal seriesJournal of Biological Physics, ISSN 0092-0606, [1573-0689]
Issue year2013
Vol39
No1
Pages67-80
Keywords in EnglishBiochemistry, general, Biophysics and Biological Physics, Heart arrhythmias, Inhomogeneous excitable media, Neurosciences, Reentry wave, Soft and Granular Matter, Complex Fluids and Microfluidics, Spiral wave, Spiral wave attraction, Spiral wave pinning, Statistical Physics, Dynamical Systems and Complexity
ASJC Classification1307 Cell Biology; 1312 Molecular Biology; 3107 Atomic and Molecular Physics, and Optics; 1304 Biophysics
DOIDOI:10.1007/s10867-012-9286-4
URL http://link.springer.com/article/10.1007/s10867-012-9286-4
Languageen angielski
Score (nominal)15
Score sourcejournalList
ScoreMinisterial score = 15.0, 01-01-2020, ArticleFromJournal
Ministerial score (2013-2016) = 15.0, 01-01-2020, ArticleFromJournal
Publication indicators Scopus Citations = 4; WoS Citations = 4; Scopus SNIP (Source Normalised Impact per Paper): 2013 = 0.608; WoS Impact Factor: 2013 = 1.152 (2) - 2013=1.346 (5)
Citation count*2 (2015-04-09)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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