Interactions of benzo[a]pyrene and diesel exhaust particulate matter with the lung surfactant system

Tomasz Robert Sosnowski , Michał Koliński , Leon Gradoń

Abstract

One of the reasons for cellular changes in the lung tissue exposed to the diesel exhaust composed of soot particles with adsorbed volatile organic molecules is the reduction of the clearance rate in the pulmonary region of the respiratory system. The interaction of the fractal-like particles and organic substances with a surfactant monolayer limits its dynamic activity. The surface properties of Survanta, a purified extract of bovine lung surfactant (LS), which interacted with carbon particles (200 nm aggregates) and benzo[a]pyrene (BaP), molecules were measured with the oscillating bubble technique. The results showed a significant lowering of the dynamics of the surfactant monolayer compared to the control case (no exposure). Additional measurements of surface pressure during the monotonic compression of the air–water interface containing the major LS phospholipid, dipalmitoylphosphatidylcholine (DPPC), showed that the presence of BaP molecules in the system influenced its stability. The experimental results were supplemented with a theoretical molecular dynamics model of the interaction between BaP and DPPC molecules. The simulation results indicated the insertion of BaP molecules into the lipid layer, which explained the measured effects.
Author Tomasz Robert Sosnowski (FCPE / CIPE)
Tomasz Robert Sosnowski,,
- Chair of Integrated Process Engineering
, Michał Koliński - [International Institute of Molecular and Cell Biology]
Michał Koliński,,
-
-
, Leon Gradoń (FCPE / CIPE)
Leon Gradoń,,
- Chair of Integrated Process Engineering
Journal seriesAnnals of Occupational Hygiene, ISSN 0003-4878, (A 25 pkt)
Issue year2011
Vol55
No3
Pages329-338
Publication size in sheets0.5
Keywords in Englishaerosols, benzo[a]pyrene, clearance, diesel exhaust, molecular dynamics, phospholipids, retention, surfactants
ASJC Classification2739 Public Health, Environmental and Occupational Health; 2700 General Medicine
DOIDOI:10.1093/annhyg/mer007
URL http://annhyg.oxfordjournals.org/content/55/3/329
Languageen angielski
File
Sosnowski T.R. (i in.) - Interactions of benzo[a]pyrene....pdf 458.31 KB
Score (nominal)25
Publication indicators Scopus Citations = 23; WoS Citations = 21; Scopus SNIP (Source Normalised Impact per Paper): 2014 = 1.556; WoS Impact Factor: 2011 = 1.949 (2) - 2011=2.084 (5)
Citation count*29 (2020-01-17)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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