Classification of amino acids and oligopeptides with the use of multi-mode chemical images obtained with ion selective electrode array

Patrycja Ciosek , Martyna Jańczyk , Wojciech Wróblewski

Abstract

The analysis of amino acids and oligopeptides as important bioanalytes is a significant task in medical diagnostics and proteomic research and currently it is based on chromatographic and electrophoretic methods. In this paper, an approach based on sensor array coupled with titration is proposed for effective recognition of 5 amino acids and 4 oligopeptides. It is shown, that the increase of information gained during measurements of sensors’ signals in various pH allows for capturing more data on interaction of amino acids and oligopeptides with various polymeric membranes of potentiometric electrodes used in the array, and that leads to the lowering of classification errors in partial least squares analysis.
Author Patrycja Ciosek (FC / IBC / DM)
Patrycja Ciosek,,
- Department Of Microbioanalytics
, Martyna Jańczyk (FC / IBC / DM)
Martyna Jańczyk,,
- Department Of Microbioanalytics
, Wojciech Wróblewski (FC / IBC / DM)
Wojciech Wróblewski,,
- Department Of Microbioanalytics
Journal seriesAnalytica Chimica Acta, ISSN 0003-2670, (A 40 pkt)
Issue year2011
Vol699
No1
Pages26-32
Keywords in EnglishAmino acids, Electronic tongue, Oligopeptides, Partial least squares-discriminant analysis, Sensor array
ASJC Classification1607 Spectroscopy; 2304 Environmental Chemistry; 1303 Biochemistry; 1602 Analytical Chemistry
DOIDOI:10.1016/j.aca.2011.05.013
URL http://www.sciencedirect.com/science/article/pii/S0003267011006520
Languageen angielski
Score (nominal)40
Score sourcejournalList
Publication indicators WoS Citations = 3; Scopus Citations = 3; Scopus SNIP (Source Normalised Impact per Paper): 2011 = 1.759; WoS Impact Factor: 2011 = 4.555 (2) - 2011=4.144 (5)
Citation count*4 (2016-05-09)
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