Interfacial rheology for the assessment of potential health effects of inhaled carbon nanomaterials at variable breathing conditions

Dorota Kondej , Tomasz Robert Sosnowski

Abstract

Lung surface is the first line of contact between inhaled carbon nanomaterials, CNMs, and the organism, so this is the place where pulmonary health effects begin. The paper analyzes the influence of several CNMs (single- and multi-walled nanotubes with various surface area: 90–1,280 m2/g and aspect ratio: 8–3,750) on the surface-active properties of the lung surfactant, LS, model (Survanta). Effects of CNM concentration (0.1–1 mg/ml) and surface oscillation rate were determined using the oscillating drop method at simulated breathing conditions (2–10 s per cycle, 37 °C). Based on the values of apparent elasticity and viscosity of the interfacial region, new parameters: Sε and Sμ were proposed to evaluate potential effect of particles on the LS at various breathing rates. Some of tested CNMs (e.g., COOH- functionalized short nanotubes) significantly influenced the surfactant dynamics, while the other had weaker effects even at high particle concentration. Analysis of changes in Sε and Sμ provides a new way to evaluate of a possible disturbance of the basic functions of LS. The results show that the expected pulmonary effects caused by inhaled CNMs at variable breathing rate depend not only on particle concentration (inhaled dose) but also on their size, structure and surface properties.
Author Dorota Kondej - Centralny Instytut Ochrony Pracy - Państwowy Instytut Badawczy (CIOP PIB)
Dorota Kondej,,
-
, Tomasz Robert Sosnowski (FCPE / CIPE)
Tomasz Robert Sosnowski,,
- Chair of Integrated Process Engineering
Journal seriesScientific Reports, ISSN 2045-2322
Issue year2020
Vol10
No1
Pages1-10
Publication size in sheets0.5
Article number14044
ASJC Classification1000 Multidisciplinary
DOIDOI:10.1038/s41598-020-70909-y
URL https://www.nature.com/articles/s41598-020-70909-y
Languageen angielski
LicenseJournal (articles only); author's original; Uznanie Autorstwa (CC-BY); after publication
File
s41598-020-70909-y.pdf 1.45 MB
Score (nominal)140
Score sourcejournalList
ScoreMinisterial score = 140.0, 14-09-2020, ArticleFromJournal
Publication indicators Scopus SNIP (Source Normalised Impact per Paper): 2016 = 1.401; WoS Impact Factor: 2018 = 4.011 (2) - 2018=4.525 (5)
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