Interfacial rheology for the assessment of potential health effects of inhaled carbon nanomaterials at variable breathing conditions
Authors:
- Dorota Kondej,
- Tomasz Robert Sosnowski
Abstract
Lung surface is the first line of contact between inhaled carbon nanomaterials, CNMs, and the organism, so this is the place where pulmonary health effects begin. The paper analyzes the influence of several CNMs (single- and multi-walled nanotubes with various surface area: 90–1,280 m2/g and aspect ratio: 8–3,750) on the surface-active properties of the lung surfactant, LS, model (Survanta). Effects of CNM concentration (0.1–1 mg/ml) and surface oscillation rate were determined using the oscillating drop method at simulated breathing conditions (2–10 s per cycle, 37 °C). Based on the values of apparent elasticity and viscosity of the interfacial region, new parameters: Sε and Sμ were proposed to evaluate potential effect of particles on the LS at various breathing rates. Some of tested CNMs (e.g., COOH- functionalized short nanotubes) significantly influenced the surfactant dynamics, while the other had weaker effects even at high particle concentration. Analysis of changes in Sε and Sμ provides a new way to evaluate of a possible disturbance of the basic functions of LS. The results show that the expected pulmonary effects caused by inhaled CNMs at variable breathing rate depend not only on particle concentration (inhaled dose) but also on their size, structure and surface properties.
- Record ID
- WUT10122e796acb47d0b08135fde318cc5c
- Author
- Journal series
- Scientific Reports, ISSN 2045-2322, other
- Issue year
- 2020
- Vol
- 10
- No
- 1
- Pages
- 1-10
- Publication size in sheets
- 0.50
- Article number
- 14044
- ASJC Classification
- DOI
- DOI:10.1038/s41598-020-70909-y Opening in a new tab
- URL
- https://www.nature.com/articles/s41598-020-70909-y Opening in a new tab
- Language
- (en) English
- License
- File
-
- File: 1
- Interfacial rheology for the assessment of potential health effects of inhaled carbon nanomaterials at variable breathing conditions, File s41598-020-70909-y.pdf / 1 MB
- s41598-020-70909-y.pdf
- publication date: 14-09-2020
- Interfacial rheology for the assessment of potential health effects of inhaled carbon nanomaterials at variable breathing conditions, File s41598-020-70909-y.pdf / 1 MB
-
- Score (nominal)
- 140
- Score source
- journalList
- Score
- = 140.0, 02-05-2022, ArticleFromJournal
- Publication indicators
- = 7; = 1; = 7; : 2016 = 1.401; : 2020 (2 years) = 4.380 - 2020 (5 years) =5.134
- Citation count
- 9
- Uniform Resource Identifier
- https://repo.pw.edu.pl/info/article/WUT10122e796acb47d0b08135fde318cc5c/
- URN
urn:pw-repo:WUT10122e796acb47d0b08135fde318cc5c
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or PerishOpening in a new tab system.