Fabrication, multi-scale characterization and in-vitro evaluation of porous hybrid bioactive glass polymer-coated scaffolds for bone tissue engineering

Adrian Chlanda , Przemysław Oberbek , Marcin Heljak , Ewa Kijeńska-Gawrońska , Tomasz Bolek , Michał Gloc , Łukasz John , Mateusz Janeta , Michał Woźniak

Abstract

Bioactive glass-based scaffolds are commonly used in bone tissue engineering due to their biocompatibility, mechanical strength and adequate porous structure. However, their hydrophobicity and brittleness limits their practical application. In this study, to improve nanomechanical properties of such scaffolds, pure bioactive hybrid glass and two bioactive hybrid glass-polymer coated composites were fabricated. A complementary micro and nanoscale characterization techniques (SEM, AFM, μCT, FTIR, compressive test, goniometer) were implemented for detailed description of architecture and physicochemical properties of hybrid bioactive glass-based scaffolds with emphasis on nano-mechanics. The final step was in-vitro evaluation of three dimensional macroporous structures. Our findings show that after polymer addition, architecture, topography and surface properties of the scaffolds were changed and promoted favoured behaviour of the cells.
Author Adrian Chlanda (FMSE / DMD)
Adrian Chlanda,,
- Division of Materials Design
, Przemysław Oberbek (FMSE / DMD)
Przemysław Oberbek,,
- Division of Materials Design
, Marcin Heljak (FMSE / DMD)
Marcin Heljak,,
- Division of Materials Design
, Ewa Kijeńska-Gawrońska (FMSE / DMD)
Ewa Kijeńska-Gawrońska,,
- Division of Materials Design
, Tomasz Bolek (FMSE / DMD)
Tomasz Bolek,,
- Division of Materials Design
, Michał Gloc (FMSE / DMD)
Michał Gloc,,
- Division of Materials Design
, Łukasz John - [University of Wroclaw]
Łukasz John,,
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, Mateusz Janeta - [University of Wroclaw]
Mateusz Janeta,,
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, Michał Woźniak - [Politechnika Warszawska]
Michał Woźniak,,
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Journal seriesMaterials Science & Engineering C - Materials for Biological Applications, ISSN 0928-4931, (A 30 pkt)
Issue year2019
Vol94
Pages516-523
Publication size in sheets0.5
Keywords in PolishInżynieria tkankowa, Rusztowania, Szkło bioaktywne, Właściwości mechaniczne
Keywords in EnglishTissue engineering, Scaffold, Bioactive glass, Mechanical properties
ASJC Classification2210 Mechanical Engineering; 2211 Mechanics of Materials; 3104 Condensed Matter Physics; 2500 General Materials Science
DOIDOI:10.1016/j.msec.2018.09.062
URL https://www.sciencedirect.com/science/article/pii/S0928493118308385
Languageen angielski
File
msec.pdf 1.84 MB
Score (nominal)30
ScoreMinisterial score = 30.0, 25-04-2019, ArticleFromJournal
Ministerial score (2013-2016) = 30.0, 24-01-2019, ArticleFromJournal
Publication indicators Scopus Citations = 1; WoS Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2017 = 1.384; WoS Impact Factor: 2017 = 5.08 (2) - 2017=4.628 (5)
Citation count*3 (2019-07-18)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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