Optimization of poly(glycerol sebacate) synthesis for biomedical purposes with the Design of Experiments
Agnieszka Gadomska-Gajadhur , Michał Wrzecionek , G. Matyszczak , Piotr Piętowski , M. Więcław , Paweł Ruśkowski
AbstractEﬃcient, original synthesis of poly(glycerol sebacate) (PGS) via polycondensation of glycerine and sebacic acid 9 was achieved. The process was successfully optimized by using the Box−Behnken design. PGS was obtained with a high 10 conversion of the carboxylic group (89%) and a very high degree of esteriﬁcation (∼82%), containing no catalysts residues. A 11 method was developed for puriﬁcation of prepolymer PGS. Because biocompatible substrates are used, this method for 12 obtaining the polymer can be used in medical and pharmaceutical applications.
|Journal series||Organic Process Research & Development, ISSN 1083-6160|
|Publication size in sheets||0.5|
|Keywords in Polish||xxx|
|Keywords in English||poly (glycerol sebacate), polycondensation, biodegradable polymers, biomedical applications, DOE|
|Abstract in Polish||xxx|
|Score||= 35.0, 03-08-2020, ArticleFromJournal|
|Publication indicators||= 1; = 2; = 4.0; : 2017 = 0.978; : 2018 = 3.327 (2) - 2018=3.171 (5)|
|Citation count*||4 (2020-07-27)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.