Optimization of poly(glycerol sebacate) synthesis for biomedical purposes with the Design of Experiments

Agnieszka Gadomska-Gajadhur , Michał Wrzecionek , G. Matyszczak , Piotr Piętowski , M. Więcław , Paweł Ruśkowski

Abstract

Efficient, original synthesis of poly(glycerol sebacate) (PGS) via polycondensation of glycerine and sebacic acid 9 was achieved. The process was successfully optimized by using the Box−Behnken design. PGS was obtained with a high 10 conversion of the carboxylic group (89%) and a very high degree of esterification (∼82%), containing no catalysts residues. A 11 method was developed for purification of prepolymer PGS. Because biocompatible substrates are used, this method for 12 obtaining the polymer can be used in medical and pharmaceutical applications.
Author Agnieszka Gadomska-Gajadhur (FC / LTP)
Agnieszka Gadomska-Gajadhur,,
- Laboratory Of Technological Processes
, Michał Wrzecionek (FC / LTP)
Michał Wrzecionek,,
- Laboratory Of Technological Processes
, G. Matyszczak (FC / LTP)
G. Matyszczak,,
- Laboratory Of Technological Processes
, Piotr Piętowski - [Politechnika Warszawska]
Piotr Piętowski,,
-
-
, M. Więcław
M. Więcław,,
-
, Paweł Ruśkowski (FC / LTP)
Paweł Ruśkowski,,
- Laboratory Of Technological Processes
Journal seriesOrganic Process Research & Development, ISSN 1083-6160, (A 35 pkt)
Issue year2018
Vol22
No12
Pages1793-1800
Publication size in sheets0.5
Keywords in Polishxxx
Keywords in Englishpoly (glycerol sebacate), polycondensation, biodegradable polymers, biomedical applications, DOE
ASJC Classification1605 Organic Chemistry; 1606 Physical and Theoretical Chemistry
Abstract in Polishxxx
DOIDOI:10.1021/acs.oprd.8b00306
Languageen angielski
File
wdpb_publikacje_pliki_plik_publikacja_3597_org.pdf 2.06 MB
Score (nominal)35
ScoreMinisterial score = 35.0, 06-09-2019, ArticleFromJournal
Publication indicators WoS Citations = 1; Scopus Citations = 1; Scopus SNIP (Source Normalised Impact per Paper): 2017 = 0.978; WoS Impact Factor: 2017 = 3.584 (2) - 2017=3.109 (5)
Citation count*1 (2019-09-10)
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* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.
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