Optimization of poly(glycerol sebacate) synthesis for biomedical purposes with the Design of Experiments
Agnieszka Gadomska-Gajadhur , Michał Wrzecionek , G. Matyszczak , Piotr Piętowski , M. Więcław , Paweł Ruśkowski
AbstractEﬃcient, original synthesis of poly(glycerol sebacate) (PGS) via polycondensation of glycerine and sebacic acid 9 was achieved. The process was successfully optimized by using the Box−Behnken design. PGS was obtained with a high 10 conversion of the carboxylic group (89%) and a very high degree of esteriﬁcation (∼82%), containing no catalysts residues. A 11 method was developed for puriﬁcation of prepolymer PGS. Because biocompatible substrates are used, this method for 12 obtaining the polymer can be used in medical and pharmaceutical applications.
|Journal series||Organic Process Research & Development, ISSN 1083-6160, (A 35 pkt)|
|Publication size in sheets||0.5|
|Keywords in Polish||xxx|
|Keywords in English||poly (glycerol sebacate), polycondensation, biodegradable polymers, biomedical applications, DOE|
|Abstract in Polish||xxx|
|Score|| = 35.0, 11-03-2019, ArticleFromJournal|
= 35.0, 11-03-2019, ArticleFromJournal
|Publication indicators||= 0; : 2017 = 0.978; : 2017 = 3.584 (2) - 2017=3.109 (5)|
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