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Cylindrical polyurethane scaffold fabricated using the phase inversion method: Influence of process parameters on scaffolds’ morphology and mechanical properties
Authors:
- Aleksandra Kuźmińska,
- Dominika Kwarta,
- Tomasz Ciach,
- Beata Aleksandra Butruk-Raszeja
- Record ID
- WUT04acab290a25434d8b764bee664ffdb6
- Author
- Journal series
- Materials, ISSN 1996-1944
- Issue year
- 2021
- Vol
- 14
- No
- 11
- Pages
- 1-21
- Article number
- 2977
- Keywords in English
- phase inversion technique, tissue scaffold, polyurethane, surface porous
- ASJC Classification
- Abstract in original language
- This work presents a method of obtaining cylindrical polymer structures with a given diameter (approx. 5 mm) using the phase inversion technique. As part of the work, the influence of process parameters (polymer hardness, polymer solution concentration, the composition of the non-solvent solution, process time) on the scaffolds’ morphology was investigated. Additionally, the influence of the addition of porogen on the scaffold’s mechanical properties was analyzed. It has been shown that the use of a 20% polymer solution of medium hardness (ChronoFlex C45D) and carrying out the process for 24 h in 0:100 water/ethanol leads to the achievement of repeatable structures with adequate flexibility. Among the three types of porogens tested (NaCl, hexane, polyvinyl alcohol), the most favorable results were obtained for 10% polyvinyl alcohol (PVA). The addition of PVA increases the range of pore diameters and the value of the mean pore diameter (9.6 ± 3.2 vs. 15.2 ± 6.4) while reducing the elasticity of the structure (Young modulus = 3.6 ± 1.5 MPa vs. 9.7 ± 4.3 MPa).
- DOI
- DOI:10.3390/ma14112977 Opening in a new tab
- URL
- https://www.mdpi.com/1996-1944/14/11/2977 Opening in a new tab
- Language
- eng (en) English
- File
-
- File: 1
- Kuźmińska A. (i in.) - Cylindrical polyurethane scaffold....pdf
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- Score (nominal)
- 140
- Score source
- journalList
- Score
- = 140.0, 01-06-2021, ArticleFromJournal
- Publication indicators
- : 2017 = 1.285; : 2018 (2 years)= 2.972 - 2018 (5 years)=3.532
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- Uniform Resource Identifier
- https://repo.pw.edu.pl/info/article/WUT04acab290a25434d8b764bee664ffdb6/
- URN
urn:pw-repo:WUT04acab290a25434d8b764bee664ffdb6
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or PerishOpening in a new tab system.