Application of porogenes in production of porous polymers by supercritical foaming

Katarzyna Sawicka , Katarzyna Kosowska , Marek Henczka

Abstract

Biocomposite foam scaffolds of poly(ε-caprolactone) (PCL) with different porogenes were produced with batch foaming technique using supercritical carbon dioxide (scCO2) as a blowing agent. In performed experiments composites were prepared from graphene-oxide (nGO), nano-hydroxyapatite (nHA) and nano-cellulose (nC), with various concentrations. The objective of the study was to explore the effects of porogen concentration and foaming process parameters on the morphology and mechanical properties of three-dimensional porous structures that can be used as temporary scaffolds in tissue engineering. The structures were manufactured using scCO2 as a blowing agent, at two various foaming pressures (9 MPa and 18 MPa), at three different temperatures (323 K, 343 K and 373 K) for different saturation times (0.5 h, 1 h and 4 h). In order to examine the utility of porogenes, a number of tests, such as static compression tests, thermal analysis and scanning electron microscopy, have been performed. Analysis of experimental results showed that the investigated materials demonstrated high mechanical strength and a wide range of pore sizes. The obtained results suggest that PCL porous structures are useful as biodegradable and biocompatible scaffolds for tissue engineering.
Author Katarzyna Sawicka (FCPE)
Katarzyna Sawicka,,
- Faculty of Chemical and Process Engineering
, Katarzyna Kosowska (FCPE / DCRED)
Katarzyna Kosowska,,
- Department of Chemical Reactor Engineering and Dynamics
, Marek Henczka (FCPE / DCRED)
Marek Henczka,,
- Department of Chemical Reactor Engineering and Dynamics
Journal seriesChemical and Process Engineering , [Inżynieria Chemiczna i Procesowa], ISSN 0208-6425, (A 15 pkt)
Issue year2019
Vol40
No1
Pages115-122
Publication size in sheets0.5
Keywords in Englishtissue engineering, supercritical fluids, foaming, poly(ε-caprolactone), porogenes
ASJC Classification1500 General Chemical Engineering; 1600 General Chemistry
DOIDOI:10.24425/cpe.2019.126105
URL http://journals.pan.pl/dlibra/publication/126105/edition/110017/content
Languageen angielski
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Sawicka K. (i in.) - Application of porogenes...pdf 688.62 KB
Score (nominal)15
ScoreMinisterial score = 15.0, 05-09-2019, ArticleFromJournal
Publication indicators WoS Citations = 0; Scopus Citations = 0; Scopus SNIP (Source Normalised Impact per Paper): 2017 = 0.701; WoS Impact Factor: 2017 = 0.892 (2) - 2017=0.894 (5)
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