Experimental evaluation of importance of the pulmonary surfactant for oxygen transfer rate in human lungs
Tomasz Robert Sosnowski , Leon Gradoń , Magdalena Skoczek , Hanna Droździel
AbstractThe rate of oxygen transport from atmospheric air into water and perfluorocarbon compound (PFC) was investigated. Static and dynamic systems with and without the presence of the lung surfactant monolayer were considered. For the case of water used as an oxygen absorbent, the monolayer activity allowed a simulation of the gas uptake into the lung hypophase. In the second case, a two-phase liquid system with water as a hypophase and PFC as the blood substitute simulated oxygen transport in the alveolus-blood system. Original experimental measurement devices gave the opportunity of determining the gas transport rate with the possibilities of indicating the role of the lung surfactant in the process and evaluating the influence of environmental conditions on the transport phenomena. Results of that work suggest a possible enhancing role of the lung surfactant in the oxygen transfer rate.
|Journal series||International Journal of Occupational Safety and Ergonomics, ISSN 1080-3548|
|Publication size in sheets||0.9|
|Keywords in English||lung surfactant, blood oxygenation, perfluorocarbon compound|
|Publication indicators||: 2008 = 0.405 (2) - 2011=0.347 (5)|
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